Quercetin enhances pretumorous lesions in the NMU model of rat pancreatic carcinogenesis

被引：22

作者：

Barotto, NN

López, CB

Eynard, AR

Zapico, MEF

Valentich, MA ^{[1
]}

机构：

[1] Univ Nacl Cordoba, Fac Ciencias Med, IIda Catedra Histol, RA-5000 Cordoba, Argentina

[2] Univ Nacl Cordoba, Fac Ciencias Med, Inst Biol Celular, RA-5000 Cordoba, Argentina

[3] CONICET, RA-5000 Cordoba, Argentina

[4] Univ Nacl Cordoba, Fac Ciencias Med, Ira Catedra Histol, RA-5000 Cordoba, Argentina

来源：

CANCER LETTERS | 1998年 / 129卷 / 01期

关键词：

quercetin; nitrosomethylurea; promotion; progression; pancreatic carcinogenesis;

D O I：

10.1016/S0304-3835(98)00033-0

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

The effect of dietary quercetin (Q) was evaluated in rats treated with nitrosomethylurea (NMU). Pancreatic nodules and focal acinar cell hyperplasias were observed in groups treated with NMU (87%) and Q-NMU (100%). Although rats with dysplastic foci (27%) were found in the NMU-treated group, Q-NMU treatment resulted in a significantly higher number of rats with dysplastic foci (73%). Furthermore, carcinomas in situ (12%) and one microcarcinoma (4%) were found in these animals. Mitosis was significantly increased and apoptosis was diminished in focal acinar cell hyperplasias of the Q-NMU group. Our present results support a promoting and progressing effect of quercetin in the NMU model of rat pancreatic carcinogenesis. (C) 1998 Elsevier Science Ireland Ltd. All rights reserved.

引用

页码：1 / 6

页数：6

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