Alcohol's Role in HIV Transmission and Disease Progression

被引：2

作者：

Pandrea, Ivona ^{[1
]}

Happel, Kyle I.

Amedee, Angela M.

Bagby, Gregory J.

Nelson, Steve ^{[2
]}

机构：

[1] Tulane Natl Res Primate Ctr, Covington, LA USA

[2] Louisiana State Univ, Sch Med, Hlth Sci Ctr, New Orleans, LA USA

来源：

ALCOHOL RESEARCH & HEALTH | 2010年 / 33卷 / 03期

关键词：

Alcohol and other drug (AOD) use; abuse and dependence; AOD effects; disease factor; disease complication; immune system; human immunodeficiency virus (HIV); HIV infection; acquired immune deficiency syndrome; antiretroviral therapy; simian immunodeficiency virus; animal models; rhesus macaques; SIMIAN-IMMUNODEFICIENCY-VIRUS; T-CELL DEPLETION; ACUTE ETHANOL TREATMENT; HEPATITIS-C-VIRUS; SEXUALLY-TRANSMITTED-DISEASES; LUNG CHEMOKINE PRODUCTION; HUMORAL IMMUNE-RESPONSES; NECROSIS-FACTOR-ALPHA; HERPES-SIMPLEX VIRUS; ANTIRETROVIRAL THERAPY;

D O I：

暂无

中图分类号：

R194 [卫生标准、卫生检查、医药管理];

学科分类号：

摘要：

Alcohol use has negative effects on HIV disease progression through several mechanisms, including transmission, viral replication, host immunity, and treatment efficacy. Research with animal models has explored the effect of alcohol intake on several aspects of simian immunodeficiency virus (SIV) disease progression. Data suggest that the increased SIV levels observed in alcohol-consuming animals may represent an increase in virus production as opposed to a decrease in host defense. Results also suggest that changes in nutritional balance and metabolism, as a possible consequence of a proinflammatory state, together with increased virus production in animals consuming alcohol, accelerate SIV and possibly HIV disease progression. Further studies using the animal model are necessary.

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页码：203 / 218

页数：16

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