Conditioning regimens for allogeneic hematopoietic stem cell transplants in acute myeloid leukemia

被引：68

作者：

Jethava, Y. S. ^{[1
]}

Sica, S. ^{[2
]}

Savani, B. ^{[3
]}

Socola, F. ^{[1
]}

Jagasia, M. ^{[3
]}

Mohty, M. ^{[4
]}

Nagler, A. ^{[5
,6
]}

Bacigalupo, A. ^{[2
]}

机构：

[1] Univ Arkansas Med Sci, Div Hematol, Dept Internal Med, 4301 W Markham St 508, Little Rock, AR 72205 USA

[2] Univ Cattolica Sacro Cuore, Inst Haematol, Rome, Italy

[3] Vanderbilt Univ Sch Med, Dept Hematol, Nashville, TN USA

[4] Hop St Antoine, Serv Hematol Clin & Therapie Cellulaire, Paris, France

[5] Chaim Sheba Med Ctr, Hematol Div, Ramat Gan, Israel

[6] Tel Aviv Univ, Ramat Gan, Israel

来源：

BONE MARROW TRANSPLANTATION | 2017年 / 52卷 / 11期

关键词：

TOTAL-BODY IRRADIATION; BONE-MARROW-TRANSPLANTATION; CORD BLOOD TRANSPLANTATION; BUSULFAN PLUS CYCLOPHOSPHAMIDE; ACUTE MYELOGENOUS LEUKEMIA; UNRELATED DONOR TRANSPLANTATION; ACUTE NONLYMPHOBLASTIC LEUKEMIA; COLONY-STIMULATING FACTOR; REDUCED-INTENSITY; MYELODYSPLASTIC SYNDROME;

D O I：

10.1038/bmt.2017.83

中图分类号：

Q6 [生物物理学];

学科分类号：

071011 ;

摘要：

AML is currently the first indication for allogeneic hematopoietic stem cell transplantation (allo-HSCT), as shown by international transplant registries. The conditioning regimens are classified as myeloablative conditioning, non-myeloablative or reduced intensity conditioning. Targeted radioimmunotherapy such as anti-CD45 antibody have also been added to the conditioning regimen in an attempt to improve tumor cell kill. Refinement of standard regimens has led to a reduction of non-relapse mortality, also in the older age group over 60 or 70 years of age. Relapse post allo-HSCT remains an important issue, especially for patients who undergo transplant with residual or refractory disease. In these patients, pre- and post-transplant interventions need to be considered.

引用

页码：1504 / 1511

页数：8

共 68 条

[31] Conditioning including antithymocyte globulin followed by unmanipulated HLA-mismatched/haploidentical blood and marrow transplantation can achieve comparable outcomes with HLA-identical sibling transplantation [J].

Lu, DP ;

Dong, LJ ;

Wu, T ;

Huang, XJ ;

Zhang, MJ ;

Han, W ;

Chen, H ;

Liu, DH ;

Gao, ZY ;

Chen, YH ;

Xu, LP ;

Zhang, YC ;

Ren, HY ;

Li, D ;

Liu, KY .

BLOOD, 2006, 107 (08) :3065-3073

[32] Phase II prospective study of treosulfan-based reduced-intensity conditioning in allogeneic HSCT for hematological malignancies from 10/10 HLA-identical unrelated donor [J].

Michallet, Mauricette ;

Sobh, Mohamad ;

Milpied, Noel ;

Bay, Jacques-Olivier ;

Fuerst, Sabine ;

Harousseau, Jean-Luc ;

Mohty, Mohamad ;

Nicolini, Franck E. ;

Labussiere, Helene ;

Tedone, Nathalie ;

Morisset, Stephane ;

Vigouroux, Stephane ;

Baumgart, Joachim ;

Tabrizi, Reza ;

Blaise, Didier .

ANNALS OF HEMATOLOGY, 2012, 91 (08) :1289-1297

[33] Induction of natural killer T cell-dependent alloreactivity by administration of granulocyte colony-stimulating factor after bone marrow transplantation [J].

Morris, Edward S. ;

MacDonald, Kelli P. A. ;

Kuns, Rachel D. ;

Morris, Helen M. ;

Banovic, Tatjana ;

Don, Alistair L. J. ;

Rowe, Vanessa ;

Wilson, Yana A. ;

Raffelt, Neil C. ;

Engwerda, Christian R. ;

Burman, Angela C. ;

Markey, Kate A. ;

Godfrey, Dale I. ;

Smyth, Mark J. ;

Hill, Geoffrey R. .

NATURE MEDICINE, 2009, 15 (04) :436-441

[34] Allogeneic Hematopoietic Stem-Cell Transplantation for Acute Myeloid Leukemia in Remission: Comparison of Intravenous Busulfan Plus Cyclophosphamide (Cy) Versus Total-Body Irradiation Plus Cy As Conditioning Regimen-A Report From the Acute Leukemia Working Party of the European Group for Blood and Marrow Transplantation [J].

Nagler, Arnon ;

Rocha, Vanderson ;

Labopin, Myriam ;

Unal, Ali ;

Ben Othman, Tarek ;

Campos, Antonio ;

Volin, Liisa ;

Poire, Xavier ;

Aljurf, Mahmoud ;

Masszi, Tamas ;

Socie, Gerard ;

Sengelov, Henrik ;

Michallet, Mauricette ;

Passweg, Jakob ;

Veelken, Hendrik ;

Yakoub-Agha, Ibrahim ;

Shimoni, Avichai ;

Mohty, Mohamad .

JOURNAL OF CLINICAL ONCOLOGY, 2013, 31 (28) :3549-+

[35] Busulphan in Blood and Marrow Transplantation: Dose, Route, Frequency and Role of Therapeutic Drug Monitoring [J].

Nath, Christa Ellen ;

Shaw, Peter John .

CURRENT CLINICAL PHARMACOLOGY, 2007, 2 (01) :75-91

[36] Nonmyeloablative bone marrow transplantation from partially HLA-mismatched related donors using posttransplantation cyclophosphamide [J].

O'Donnell, PV ;

Luznik, L ;

Jones, RJ ;

Vogelsang, GB ;

Leffell, MS ;

Phelps, M ;

Rhubart, P ;

Cowan, K ;

Piantadosi, S ;

Fuchs, EJ .

BIOLOGY OF BLOOD AND MARROW TRANSPLANTATION, 2002, 8 (07) :377-386

[37] Effect of Conditioning Regimen Intensity on Acute Myeloid Leukemia Outcomes after Umbilical Cord Blood Transplantation [J].

Oran, Betul ;

Wagner, John E. ;

DeFor, Todd E. ;

Weisdorf, Daniel J. ;

Brunstein, Claudio G. .

BIOLOGY OF BLOOD AND MARROW TRANSPLANTATION, 2011, 17 (09) :1327-1334

[38] How I treat the older patient with acute myeloid leukemia [J].

Ossenkoppele, Gert ;

Lowenberg, Bob .

BLOOD, 2015, 125 (05) :767-774

[39] 131I-anti-CD45 antibody plus busulfan and cyclophosphamide before allogeneic hematopoietic cell transplantation for treatment of acute myeloid leukemia in first remission [J].

Pagel, JM ;

Appelbaum, FR ;

Eary, JF ;

Rajendran, J ;

Fisher, DR ;

Gooley, T ;

Ruffner, K ;

Nemecek, E ;

Sickle, E ;

Durack, L ;

Carreras, J ;

Horowitz, MM ;

Press, OW ;

Gopal, AK ;

Martin, PJ ;

Bernstein, ID ;

Matthews, DC .

BLOOD, 2006, 107 (05) :2184-2191

[40] Allogeneic hematopoietic cell transplantation after conditioning with 131I-anti-CD45 antibody plus fludarabine and low-dose total body irradiation for elderly patients with advanced acute myeloid leukemia or high-risk myelodysplastic syndrome [J].

Pagel, John M. ;

Gooley, Theodore A. ;

Rajendran, Joseph ;

Fisher, Darrell R. ;

Wilson, Wendy A. ;

Sandmaier, Brenda M. ;

Matthews, Dana C. ;

Deeg, H. Joachim ;

Gopal, Ajay K. ;

Martin, Paul J. ;

Storb, Rainer F. ;

Press, Oliver W. ;

Appelbaum, Frederick R. .

BLOOD, 2009, 114 (27) :5444-5453

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