Conditioning regimens for allogeneic hematopoietic stem cell transplants in acute myeloid leukemia

被引：68

作者：

Jethava, Y. S. ^{[1
]}

Sica, S. ^{[2
]}

Savani, B. ^{[3
]}

Socola, F. ^{[1
]}

Jagasia, M. ^{[3
]}

Mohty, M. ^{[4
]}

Nagler, A. ^{[5
,6
]}

Bacigalupo, A. ^{[2
]}

机构：

[1] Univ Arkansas Med Sci, Div Hematol, Dept Internal Med, 4301 W Markham St 508, Little Rock, AR 72205 USA

[2] Univ Cattolica Sacro Cuore, Inst Haematol, Rome, Italy

[3] Vanderbilt Univ Sch Med, Dept Hematol, Nashville, TN USA

[4] Hop St Antoine, Serv Hematol Clin & Therapie Cellulaire, Paris, France

[5] Chaim Sheba Med Ctr, Hematol Div, Ramat Gan, Israel

[6] Tel Aviv Univ, Ramat Gan, Israel

来源：

BONE MARROW TRANSPLANTATION | 2017年 / 52卷 / 11期

关键词：

TOTAL-BODY IRRADIATION; BONE-MARROW-TRANSPLANTATION; CORD BLOOD TRANSPLANTATION; BUSULFAN PLUS CYCLOPHOSPHAMIDE; ACUTE MYELOGENOUS LEUKEMIA; UNRELATED DONOR TRANSPLANTATION; ACUTE NONLYMPHOBLASTIC LEUKEMIA; COLONY-STIMULATING FACTOR; REDUCED-INTENSITY; MYELODYSPLASTIC SYNDROME;

D O I：

10.1038/bmt.2017.83

中图分类号：

Q6 [生物物理学];

学科分类号：

071011 ;

摘要：

AML is currently the first indication for allogeneic hematopoietic stem cell transplantation (allo-HSCT), as shown by international transplant registries. The conditioning regimens are classified as myeloablative conditioning, non-myeloablative or reduced intensity conditioning. Targeted radioimmunotherapy such as anti-CD45 antibody have also been added to the conditioning regimen in an attempt to improve tumor cell kill. Refinement of standard regimens has led to a reduction of non-relapse mortality, also in the older age group over 60 or 70 years of age. Relapse post allo-HSCT remains an important issue, especially for patients who undergo transplant with residual or refractory disease. In these patients, pre- and post-transplant interventions need to be considered.

引用

页码：1504 / 1511

页数：8

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