Sexually acquired syphilis Laboratory diagnosis, management, and prevention

被引:53
作者
Forrestel, Amy K. [1 ]
Kovarik, Carrie L. [1 ]
Katz, Kenneth A. [2 ]
机构
[1] Univ Penn, Dept Dermatol, Philadelphia, PA 19104 USA
[2] Kaiser Permanente, Dept Dermatol, San Francisco, CA USA
关键词
dermatology; sexually transmitted disease; syphilis; OF-CARE TEST; HIV-NEGATIVE PATIENTS; TREPONEMA-PALLIDUM; SECONDARY SYPHILIS; SEROLOGICAL RESPONSE; MALIGNANT SYPHILIS; ENHANCED THERAPY; SEROFAST STATE; UNITED-STATES; LUES MALIGNA;
D O I
10.1016/j.jaad.2019.02.074
中图分类号
R75 [皮肤病学与性病学];
学科分类号
100206 ;
摘要
The methods used for the laboratory diagnosis of syphilis include direct detection of Treponema pallidum subspecies pallidum and serologic testing. Serologic testing relies on both nontreponemal and treponemal tests. In newly developed reverse-sequence screening algorithms, treponemal tests are performed before nontreponemal tests. The management of syphilis requires appropriate staging, treatment, and follow-up of patients along with the prompt reporting of infections to public health authorities to assist with prevention and control efforts. Benzathine penicillin G remains the treatment of choice for all stages of syphilis. Screening of populations at higher risk for syphilis is recommended by the US Centers for Disease Control and Prevention, the US Preventive Services Task Force, and the World Health Organization. The second article in this continuing medical education series reviews the testing for and the management of sexually acquired syphilis.
引用
收藏
页码:17 / 28
页数:12
相关论文
共 96 条
  • [71] Malignant Syphilis with Ocular Involvement and Organism-Depleted Lesions
    Pleimes, M.
    Hartschuh, W.
    Kutzner, H.
    Enk, A. H.
    Hartmann, M.
    [J]. CLINICAL INFECTIOUS DISEASES, 2009, 48 (01) : 83 - 85
  • [72] Proposed mechanisms and preventative options of Jarisch-Herxheimer reactions
    Pound, MW
    May, DB
    [J]. JOURNAL OF CLINICAL PHARMACY AND THERAPEUTICS, 2005, 30 (03) : 291 - 295
  • [73] Efficacy of ceftriaxone and doxycycline in the treatment of early syphilis
    Psomas, K. C.
    Brun, M.
    Causse, A.
    Atoui, N.
    Reynes, J.
    Le Moing, V.
    [J]. MEDECINE ET MALADIES INFECTIEUSES, 2012, 42 (01): : 15 - 19
  • [74] Syphilis during pregnancy: a preventable threat to maternal-fetal health
    Rac, Martha W. F.
    Revell, Paula A.
    Eppes, Catherine S.
    [J]. AMERICAN JOURNAL OF OBSTETRICS AND GYNECOLOGY, 2017, 216 (04) : 352 - 363
  • [75] Radolf J. D., 2011, Morbidity and Mortality Weekly Report, V60, P133
  • [76] Ratnam Sam, 2005, Can J Infect Dis Med Microbiol, V16, P45
  • [77] A randomized trial of enhanced therapy for early syphilis in patients with and without human immunodeficiency virus infection
    Rolfs, RT
    Joesoef, R
    Hendershot, EF
    Rompalo, AM
    Augenbraun, MH
    Chiu, M
    Bolan, G
    Johnson, SC
    French, P
    Steen, E
    Radolf, JD
    Larsen, S
    [J]. NEW ENGLAND JOURNAL OF MEDICINE, 1997, 337 (05) : 307 - 314
  • [78] Nodular secondary syphilis
    Rosmaninho, Aristoteles
    Sanches, Madalena
    Lobo, Ines
    Alves, Rosario
    Selores, Manuela
    [J]. EUROPEAN JOURNAL OF DERMATOLOGY, 2011, 21 (01) : 136 - 137
  • [79] Response to Therapy Following Retreatment of Serofast Early Syphilis Patients With Benzathine Penicillin
    Sena, Arlene C.
    Wolff, Mark
    Behets, Frieda
    Van Damme, Kathleen
    Martin, David H.
    Leone, Peter
    McNeil, Linda
    Hook, Edward W.
    [J]. CLINICAL INFECTIOUS DISEASES, 2013, 56 (03) : 420 - 422
  • [80] Predictors of Serological Cure and Serofast State After Treatment in HIV-Negative Persons With Early Syphilis
    Sena, Arlene C.
    Wolff, Mark
    Martin, David H.
    Behets, Frieda
    Van Damme, Kathleen
    Leone, Peter
    Langley, Carol
    McNeil, Linda
    Hook, Edward W.
    [J]. CLINICAL INFECTIOUS DISEASES, 2011, 53 (11) : 1092 - 1099