Role of Oxidative Stress and Mitochondrial Dysfunction in Skeletal Muscle in Type 2 Diabetic Patients

被引：10

作者：

Diaz-Morales, Noelia ^{[1
]}

Rovira-Llopis, Susana ^{[1
,2
]}

Escribano-Lopez, Irene ^{[1
]}

Banuls, Celia ^{[1
,2
]}

Lopez-Domenech, Sandra ^{[1
]}

Falcon, Rosa ^{[1
,2
]}

de Maranon, Arantxa Martinez ^{[1
]}

Sola, Eva ^{[1
,2
]}

Jover, Ana ^{[1
]}

Roldan, Ildefonso ^{[4
]}

Diez, Jose L. ^{[5
]}

Rocha, Milagros ^{[1
,2
,3
]}

Hernandez-Mijares, Antonio ^{[1
,2
,6
]}

Victor, Victor M. ^{[1
,2
,3
]}

机构：

[1] Univ Hosp Dr Peset, Serv Endocrinol, Fdn Promot Hlth & Biomed Res Valencian Reg FISABI, Valencia 46017, Spain

[2] Univ Valencia, Inst Hlth Res INCLIVA, Valencia, Spain

[3] Univ Valencia, CIBERehd, Dept Physiol & Pharmacol, Valencia, Spain

[4] Univ Hosp Dr Peset, Serv Cardiol, Fdn Promot Hlth & Biomed Res Valencian Reg FISABI, Valencia 46017, Spain

[5] Univ Hosp Dr Peset, Serv Haematol, Fdn Promot Hlth & Biomed Res Valencian Reg FISABI, Valencia 46017, Spain

[6] Univ Valencia, Dept Med, Valencia, Spain

来源：

CURRENT PHARMACEUTICAL DESIGN | 2016年 / 22卷 / 18期

关键词：

Antioxidants; Mitochondria; Muscle; Oxidative stress; Type; 2; diabetes; HIGH-FAT DIET; INSULIN-RESISTANCE; MYOCARDIAL-INFARCTION; MOLECULAR-MECHANISMS; PROTEIN-SYNTHESIS; GENE-EXPRESSION; HEART-FAILURE; ER STRESS; GLUCOSE; PHOSPHORYLATION;

D O I：

10.2174/1381612822666160217142949

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

Type 2 diabetes can increase the risk of skeletal muscle dysfunction and, consequently, that of cardiovascular diseases, including coronary artery disease and stroke. It is also related to a reduced capacity for exercise, but the underlying mechanism is only partially understood. There are several factors that contribute to the development of skeletal muscle dysfunction, of which oxidative stress and mitochondrial dysfunction are among the most important. This review discusses the role of oxidative stress in the development and progression of skeletal and cardiac dysfunction associated with diabetes. It also provides an overview of the potential actions of antioxidants in general and mitochondria-targeted antioxidants in particular in the treatment of muscle dysfunction in type 2 diabetes.

引用

页码：2650 / 2656

页数：7

共 50 条

[21] Mitochondrial dysfunction in type 2 diabetes: A neglected path to skeletal muscle atrophy
Wu, Jian-Jun
Xian, Hui-Min
Yang, Da-Wei
Yang, Fan
WORLD JOURNAL OF ORTHOPEDICS, 2024, 15 (02): : 101 - 104
[22] Mitochondrial dysfunction and oxidative stress in diabetic wound
Jiang, Guoyong
Jiang, Tao
Chen, Jing
Yao, Haibo
Mao, Renqun
Yang, Xiaofan
Chen, Zhenbing
Li, Wenqing
JOURNAL OF BIOCHEMICAL AND MOLECULAR TOXICOLOGY, 2023, 37 (07)
[23] The Enhanced Oxidative Stress is Associated with Skeletal Muscle Abnormalities in Patients with Heart Failure
Kinugawa, Shintaro
Hirabayashi, Kagami
Suga, Tadashi
Takahashi, Masashige
Takada, Shingo
Yokota, Takashi
Okita, Koichi
Tsutsui, Hiroyuki
CIRCULATION, 2011, 124 (21)
[24] Oxidative stress-induced mitochondrial fragmentation and movement in skeletal muscle myoblasts
Iqbal, Sobia
Hood, David A.
AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY, 2014, 306 (12): : C1176 - C1183
[25] Sirtuins and Type 2 Diabetes: Role in Inflammation, Oxidative Stress, and Mitochondrial Function
Kitade, Munehiro
Ogura, Yoshio
Monno, Itaru
Koya, Daisuke
FRONTIERS IN ENDOCRINOLOGY, 2019, 10
[26] Effect of physical training on mitochondrial respiration and reactive oxygen species release in skeletal muscle in patients with obesity and type 2 diabetes
Hey-Mogensen, M.
Hojlund, K.
Vind, B. F.
Wang, L.
Dela, F.
Beck-Nielsen, H.
Fernstrom, M.
Sahlin, K.
DIABETOLOGIA, 2010, 53 (09) : 1976 - 1985
[27] Intact initiation of autophagy and mitochondrial fission by acute exercise in skeletal muscle of patients with Type 2 diabetes
Kruse, Rikke
Pedersen, Andreas J. T.
Kristensen, Jonas M.
Petersson, Stine J.
Wojtaszewski, Jorgen F. P.
Hojlund, Kurt
CLINICAL SCIENCE, 2017, 131 (01) : 37 - 47
[28] Targeting Mitochondrial DNA to Reduce Consequences of Oxidative Stress: Role in the Prevention of the Diabetic Cardiomyopathy
Guarini, Giacinta
Kolz, Christopher L.
Pung, Yuh F.
Ohanyan, Vahagn A.
Yin, Liya
Bratz, Ian N.
Marzilli, Mario
Chilian, William M.
CIRCULATION, 2011, 124 (21)
[29] Role of Mitochondrial Dynamics in Type 2 Diabetes Mellitus Dysfunction
Tajane, Tejas Dilip
Waghmare, Pranita Jwalant
Taksande, Bharati Amar
Ambulkar, Prafulla Shriram
Waghmare, Jwalant Eknath
JOURNAL OF CLINICAL AND DIAGNOSTIC RESEARCH, 2022, 16 (11) : GE1 - GE7
[30] Diastolic dysfunction in prediabetic male rats: Role of mitochondrial oxidative stress
Koncsos, Gabor
Varga, Zoltan V.
Baranyai, Tamas
Boengler, Kerstin
Rohrbach, Susanne
Li, Ling
Schlueter, Klaus-Dieter
Schreckenberg, Rolf
Radovits, Tamas
Olah, Attila
Matyas, Csaba
Lux, Arpad
Al-Khrasani, Mahmoud
Komlodi, Timea
Bukosza, Nora
Mathe, Domokos
Deres, Laszlo
Bartekova, Monika
Rajtik, Tomas
Adameova, Adriana
Szigeti, Krisztian
Hamar, Peter
Helyes, Zsuzsanna
Tretter, Laszlo
Pacher, Pal
Merkely, Bela
Giricz, Zoltan
Schulz, Rainer
Ferdinandy, Peter
AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY, 2016, 311 (04): : H927 - H943

← 1 2 3 4 5 →