Anti-tumor abietane diterpenes from the cones of Sequoia sempervirens

被引：76

作者：

Son, KH ^{[1
]}

Oh, HM ^{[1
]}

Choi, SK ^{[1
]}

Han, DC ^{[1
]}

Kwon, BM ^{[1
]}

机构：

[1] Univ Sci & Technol Korea, Korea Res Inst Biosci & Biotechnol, Taejon 305600, South Korea

来源：

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 2005年 / 15卷 / 08期

关键词：

anti-tumor; abietane diterpene; cancer cell;

D O I：

10.1016/j.bmcl.2005.02.057

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

A new abietane, namely, 20-hydroxyferruginol (1), together with known ferruginol (2), 18-hydroxyferruginol (3), sugiol (4), and 6 alpha-hydroxysugiol (5), were isolated from the cones of Sequoia sempervirens. Their structures were elucidated through spectral data. Compounds I and 5 strongly inhibited colon, lung, and breast human tumors and oncogene transformed cells with GI(50) 2-5 mu g/mL. (c) 2005 Elsevier Ltd. All rights reserved.

引用

页码：2019 / 2021

页数：3

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