Longitudinal functional health status in young adults with repaired dextro-transposition of the great arteries: A Congenital Heart Surgeons' Society study

被引：5

作者：

Jegatheeswaran, Anusha ^{[1
]}

Devlin, Paul J. ^{[1
]}

DeCampli, William M. ^{[3
]}

Welke, Karl F. ^{[4
]}

Williams, William G. ^{[1
]}

Blackstone, Eugene H. ^{[5
]}

Fuller, Stephanie ^{[6
]}

Jacobs, Marshall L. ^{[7
]}

Mussatto, Kathleen A. ^{[8
]}

Woods, Ronald K. ^{[9
]}

McCrindle, Brian W. ^{[2
]}

机构：

[1] Univ Toronto, Hosp Sick Children, Dept Surg, Div Cardiac Surg, Toronto, ON, Canada

[2] Univ Toronto, Hosp Sick Children, Dept Pediat, Div Cardiol, Toronto, ON, Canada

[3] Univ Cent Florida, Arnold Palmer Hosp Children, Coll Med, Div Cardiac Surg,Dept Surg, Orlando, FL 32816 USA

[4] Levine Childrens Hosp, Dept Surg, Div Cardiothorac Surg, Charlotte, NC USA

[5] Cleveland Clin Fdn, Lerner Res Inst, Dept Thorac & Cardiovasc Surg, 9500 Euclid Ave, Cleveland, OH 44195 USA

[6] Childrens Hosp Philadelphia, Div Cardiothorac Surg, Philadelphia, PA 19104 USA

[7] Johns Hopkins Univ, Dept Surg, Div Cardiac Surg, Baltimore, MD USA

[8] Childrens Hosp Wisconsin, Herma Heart Inst, Milwaukee, WI 53201 USA

[9] Med Coll Wisconsin, Childrens Hosp Wisconsin, Herma Heart Inst, Div Pediat Cardiothorac Surg,Dept Surg, Milwaukee, WI 53226 USA

来源：

JOURNAL OF THORACIC AND CARDIOVASCULAR SURGERY | 2020年 / 159卷 / 02期

关键词：

CHD; great vessel anomalies; transposition; database; epidemiology; quality of life; statistics; regression analysis; QUALITY-OF-LIFE; SWITCH OPERATION; LONG-TERM; CHILDREN; ADOLESCENTS; PATIENT; DISEASE;

D O I：

10.1016/j.jtcvs.2019.07.072

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Objectives: Improved survival has led to interest in functional health status (FHS) as patients with dextro-transposition of the great arteries (d-TGA) transition to adulthood. Our primary objectives were (1) evaluation of The Medical Outcomes Study Short Form-36 Health Survey (SF-36) results; (2) comparison with results of patients who completed the Child Health Questionnaire-Child Form 87 (CHQ-CF87) previously, or the PedsQL Generic Core Scales (PedsQL) survey subsequently; and (3) determination of factors associated with SF-36 domains. Methods: Survivors from the d-TGA Congenital Heart Surgeons' Society cohort (1985-1989) completed the SF-36 (2010) as a measure of FHS (n = 210; age 21-26 years). Patient characteristics, medical history, psychosocial factors, and previous adolescent CHQ-CF87 FHS assessment (2000) were explored for association with SF-36 domains, along with comparison with recent PedsQL data (2017). Results: Patients scored themselves the same/higher than published normative data in 10 of 10 SF-36 summary scores/domains and similar in 5 of 6 PedsQL summary scores/domains. Factors commonly associated with lower summary scores/domains of the SF-36 were presence of cardiac symptoms, heart condition impacting physical activity/overall health/quality of life, unemployment, and lack of postsecondary education. Less commonly associated factors were lower birth weight, greater total medication number, female sex, shorter procedure-free interval, poor health knowledge, lower family income, younger age at SF-36, living with parents, and being married. These factors accounted for 17% to 47% of the variation in FHS summary scores/domains. FHS was minimally related to d-TGA morphology and repair type. Conclusions: Patients with d-TGA surviving into adulthood, regardless of morphology or repair type, can primarily expect normal FHS. Addressing the challenges of patients with d-TGA entering adulthood requires consideration of psychosocial factors and clinical management.

引用

页码：604 / +

页数：14