Antipsychotic drugs as a risk factor for venous thromboembolism

被引:14
作者
Masopust, Jiri
Maly, Radovan
Urban, Ales
Hosak, Ladislav
Cermakova, Eva
机构
[1] Charles Univ Prague, Dept Psychiat, Fac Med, Hradec Kralove, Czech Republic
[2] Univ Hosp Hradec Kralove, Hradec Kralove, Czech Republic
[3] Charles Univ Prague, Fac Med, Dept Internal Med 1, Hradec Kralove, Czech Republic
[4] Charles Univ Prague, Fac Med, Dept Med Biophys, Hradec Kralove, Czech Republic
关键词
antipsychotic drugs; venous thrombosis and embolism; obesity; coagulation; hyperhomocysteinemia;
D O I
10.1080/13651500601017357
中图分类号
R749 [精神病学];
学科分类号
100205 ;
摘要
Objective. We assessed whether antipsychotic drugs represent a risk factor for venous thromboembolism by comparing the prevalence of antipsychotic drugs use in a population of patients with venous thromboembolism versus a group of individuals treated for hypertension. Methods. We identified 266 patients ( 141 women) diagnosed as having venous thromboembolism at the average age of 43.1 +/- 11 years who had been hospitalized in the University Hospital in Hradec Kralove from 1 January 1996 to 31 December 2004. Two hundred and seventy-four patients ( 140 women) with arterial hypertension, with an average age of 48.3 +/- 8.8 years, represented the control population. Results. Use of antipsychotic drugs was moderately more frequent in the group of patients with venous thromboembolism as compared with the control group subjects (4.89 vs. 1.82%; odds ratio 2.76; 95% confidence interval = 1.01 -7.55). Discussion. We discuss the possible mechanisms of venous thromboembolism induced by antipsychotic agents - hypoactivity, blood status, obesity, abnormal coagulation, autoimmune mechanisms, and hyperhomocysteinemia. Conclusion. Our results indicate the possibility of an increased risk for venous thromboembolism in patients using antipsychotic drugs. It is necessary to seriously consider this possible adverse effect owing to its potentially fatal consequences.
引用
收藏
页码:246 / 249
页数:4
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