GPCRdb: the G protein-coupled receptor database - an introduction

被引：150

作者：

Munk, C. ^{[1
]}

Isberg, V. ^{[1
]}

Mordalski, S. ^{[2
]}

Harpsoe, K. ^{[1
]}

Rataj, K. ^{[2
]}

Hauser, A. S. ^{[1
]}

Kolb, P. ^{[3
]}

Bojarski, A. J. ^{[2
]}

Vriend, G. ^{[4
]}

Gloriam, D. E. ^{[1
]}

机构：

[1] Univ Copenhagen, Fac Hlth & Med Sci, Dept Drug Design & Pharmacol, Copenhagen, Denmark

[2] Polish Acad Sci, Inst Pharmacol, Dept Med Chem, Krakow, Poland

[3] Univ Marburg, Dept Pharmaceut Chem, Marburg, Germany

[4] Radboudumc, Ctr Mol & Biomol Informat, Nijmegen, Netherlands

来源：

BRITISH JOURNAL OF PHARMACOLOGY | 2016年 / 173卷 / 14期

基金：

欧洲研究理事会;

关键词：

INFORMATION-SYSTEM; CRYSTAL-STRUCTURE; DRUG DISCOVERY; HUMAN GENOME; PHARMACOLOGY; ACTIVATION; FAMILIES; LIGANDS; DOCKING; TARGETS;

D O I：

10.1111/bph.13509

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

GPCRs make up the largest family of human membrane proteins and of drug targets. Recent advances in GPCR pharmacology and crystallography have shed new light on signal transduction, allosteric modulation and biased signalling, translating into new mechanisms and principles for drug design. The GPCR database, GPCRdb, has served the community for over 20years and has recently been extended to include a more multidisciplinary audience. This review is intended to introduce new users to the services in GPCRdb, which meets three overall purposes: firstly, to provide reference data in an integrated, annotated and structured fashion, with a focus on sequences, structures, single-point mutations and ligand interactions. Secondly, to equip the community with a suite of web tools for swift analysis of structures, sequence similarities, receptor relationships, and ligand target profiles. Thirdly, to facilitate dissemination through interactive diagrams of, for example, receptor residue topologies, phylogenetic relationships and crystal structure statistics. Herein, these services are described for the first time; visitors and guides are provided with good practices for their utilization. Finally, we describe complementary databases cross-referenced by GPCRdb and web servers with corresponding functionality.

引用

页码：2195 / 2207

页数：13

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