共 179 条
Transcriptional crosstalk between TGFβ and stem cell pathways in tumor cell invasion Role of EMT promoting Smad complexes
被引:280
作者:

Fuxe, Jonas
论文数: 0 引用数: 0
h-index: 0
机构:
Karolinska Inst, Dept Med Biochem & Biophys, Matrix Div, Stockholm, Sweden Karolinska Inst, Dept Med Biochem & Biophys, Matrix Div, Stockholm, Sweden

论文数: 引用数:
h-index:
机构:

Garcia de Herreros, Antonio
论文数: 0 引用数: 0
h-index: 0
机构:
IMIM Hosp del Mar, Programa Recerca Canc, Barcelona, Spain Karolinska Inst, Dept Med Biochem & Biophys, Matrix Div, Stockholm, Sweden
机构:
[1] Karolinska Inst, Dept Med Biochem & Biophys, Matrix Div, Stockholm, Sweden
[2] Cornell Univ, Weill Med Coll, Dept Cell & Dev Biol, New York, NY 10021 USA
[3] IMIM Hosp del Mar, Programa Recerca Canc, Barcelona, Spain
来源:
基金:
瑞典研究理事会;
关键词:
epithelial-mesenchymal transition;
tumor cell invasion;
cancer stem cells;
metastasis;
crosstalk;
transcriptional complexes;
TGF beta;
Wnt;
Ras;
Smad;
Snail;
EPITHELIAL-MESENCHYMAL TRANSITION;
GROWTH-FACTOR-BETA;
BREAST-CANCER CELLS;
E-CADHERIN EXPRESSION;
NF-KAPPA-B;
GLYCOGEN-SYNTHASE KINASE-3;
GENE-EXPRESSION;
IN-VIVO;
CARCINOMA-CELLS;
SNAIL TRANSCRIPTION;
D O I:
10.4161/cc.9.12.12050
中图分类号:
Q2 [细胞生物学];
学科分类号:
071009 ;
090102 ;
摘要:
Tumor cells undergoing the epithelial-mesenchymal transition (EMT) acquire the capacity to migrate, invade the stroma and metastasize. EMT cells also acquire stem cell characteristics suggesting crosstalk between EMT and pathways involved in promoting cellular stemness (stem cell pathways) and that EMT may contribute to the generation of cancer stem cells. indeed, transforming growth factor-beta (TGF beta), a major inducer of EMT, cooperates with stem cell pathways like Wnt, Ras, Hedgehog and Notch to induce EMT. A molecular basis for this cooperative signaling is indicated by recent data showing that many EMT associated transcription factors like Snail1, Zeb1/2, Twist, beta-catenin, Lef/TCF, Foxc2 and AP-1 interact with Smads and form EMT promoting Smad complexes (EPSC) engaged in either repressing epithelial genes or activating mesenchymal genes. Thus, formation and activation of EPSC represents a point of convergence between EMT and stem cell pathways. Here, we review our current understanding of the mechanisms involved in the transcriptional crosstalk between TGF beta and stem cell pathways and discuss how a fundament for the activation of these mechanisms may lead to the induction of EMT in tumors.
引用
收藏
页码:2363 / 2374
页数:12
相关论文
共 179 条
[1]
The transcription factor ZEB1 (δEF1) promotes tumour cell dedifferentiation by repressing master regulators of epithelial polarity
[J].
Aigner, K.
;
Dampier, B.
;
Descovich, L.
;
Mikula, M.
;
Sultan, A.
;
Schreiber, M.
;
Mikulits, W.
;
Brabletz, T.
;
Strand, D.
;
Obrist, P.
;
Sommergruber, W.
;
Schweifer, N.
;
Wernitznig, A.
;
Beug, H.
;
Foisner, R.
;
Eger, A.
.
ONCOGENE,
2007, 26 (49)
:6979-6988

Aigner, K.
论文数: 0 引用数: 0
h-index: 0
机构: Med Univ Vienna, Dept Med Biochem, Max F Perutz Labs, A-1030 Vienna, Austria

Dampier, B.
论文数: 0 引用数: 0
h-index: 0
机构: Med Univ Vienna, Dept Med Biochem, Max F Perutz Labs, A-1030 Vienna, Austria

Descovich, L.
论文数: 0 引用数: 0
h-index: 0
机构: Med Univ Vienna, Dept Med Biochem, Max F Perutz Labs, A-1030 Vienna, Austria

Mikula, M.
论文数: 0 引用数: 0
h-index: 0
机构: Med Univ Vienna, Dept Med Biochem, Max F Perutz Labs, A-1030 Vienna, Austria

Sultan, A.
论文数: 0 引用数: 0
h-index: 0
机构: Med Univ Vienna, Dept Med Biochem, Max F Perutz Labs, A-1030 Vienna, Austria

Schreiber, M.
论文数: 0 引用数: 0
h-index: 0
机构: Med Univ Vienna, Dept Med Biochem, Max F Perutz Labs, A-1030 Vienna, Austria

Mikulits, W.
论文数: 0 引用数: 0
h-index: 0
机构: Med Univ Vienna, Dept Med Biochem, Max F Perutz Labs, A-1030 Vienna, Austria

Brabletz, T.
论文数: 0 引用数: 0
h-index: 0
机构: Med Univ Vienna, Dept Med Biochem, Max F Perutz Labs, A-1030 Vienna, Austria

Strand, D.
论文数: 0 引用数: 0
h-index: 0
机构: Med Univ Vienna, Dept Med Biochem, Max F Perutz Labs, A-1030 Vienna, Austria

Obrist, P.
论文数: 0 引用数: 0
h-index: 0
机构: Med Univ Vienna, Dept Med Biochem, Max F Perutz Labs, A-1030 Vienna, Austria

Sommergruber, W.
论文数: 0 引用数: 0
h-index: 0
机构: Med Univ Vienna, Dept Med Biochem, Max F Perutz Labs, A-1030 Vienna, Austria

Schweifer, N.
论文数: 0 引用数: 0
h-index: 0
机构: Med Univ Vienna, Dept Med Biochem, Max F Perutz Labs, A-1030 Vienna, Austria

Wernitznig, A.
论文数: 0 引用数: 0
h-index: 0
机构: Med Univ Vienna, Dept Med Biochem, Max F Perutz Labs, A-1030 Vienna, Austria

Beug, H.
论文数: 0 引用数: 0
h-index: 0
机构: Med Univ Vienna, Dept Med Biochem, Max F Perutz Labs, A-1030 Vienna, Austria

论文数: 引用数:
h-index:
机构:

Eger, A.
论文数: 0 引用数: 0
h-index: 0
机构: Med Univ Vienna, Dept Med Biochem, Max F Perutz Labs, A-1030 Vienna, Austria
[2]
Stem cell and epithelial-mesenchymal transition markers are frequently overexpressed in circulating tumor cells of metastatic breast cancer patients
[J].
Aktas, Bahriye
;
Tewes, Mitra
;
Fehm, Tanja
;
Hauch, Siegfried
;
Kimmig, Rainer
;
Kasimir-Bauer, Sabine
.
BREAST CANCER RESEARCH,
2009, 11 (04)

Aktas, Bahriye
论文数: 0 引用数: 0
h-index: 0
机构:
Univ Duisburg Essen, Dept Gynecol & Obstet, Univ Hosp Essen, D-45122 Essen, Germany Univ Duisburg Essen, Dept Gynecol & Obstet, Univ Hosp Essen, D-45122 Essen, Germany

Tewes, Mitra
论文数: 0 引用数: 0
h-index: 0
机构:
Univ Duisburg Essen, Dept Internal Med Canc Res, Univ Hosp Essen, D-45122 Essen, Germany Univ Duisburg Essen, Dept Gynecol & Obstet, Univ Hosp Essen, D-45122 Essen, Germany

Fehm, Tanja
论文数: 0 引用数: 0
h-index: 0
机构:
Univ Hosp Tuebingen, Dept Gynecol & Obstet, D-72076 Tubingen, Germany Univ Duisburg Essen, Dept Gynecol & Obstet, Univ Hosp Essen, D-45122 Essen, Germany

Hauch, Siegfried
论文数: 0 引用数: 0
h-index: 0
机构:
AdnaGenAG, D-30853 Langenhagen, Germany Univ Duisburg Essen, Dept Gynecol & Obstet, Univ Hosp Essen, D-45122 Essen, Germany

Kimmig, Rainer
论文数: 0 引用数: 0
h-index: 0
机构:
Univ Duisburg Essen, Dept Gynecol & Obstet, Univ Hosp Essen, D-45122 Essen, Germany Univ Duisburg Essen, Dept Gynecol & Obstet, Univ Hosp Essen, D-45122 Essen, Germany

论文数: 引用数:
h-index:
机构:
[3]
Prospective identification of tumorigenic breast cancer cells
[J].
Al-Hajj, M
;
Wicha, MS
;
Benito-Hernandez, A
;
Morrison, SJ
;
Clarke, MF
.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA,
2003, 100 (07)
:3983-3988

Al-Hajj, M
论文数: 0 引用数: 0
h-index: 0
机构: Univ Michigan, Sch Med, Dept Internal Med, Ctr Comprehens Canc, Ann Arbor, MI 48109 USA

Wicha, MS
论文数: 0 引用数: 0
h-index: 0
机构: Univ Michigan, Sch Med, Dept Internal Med, Ctr Comprehens Canc, Ann Arbor, MI 48109 USA

Benito-Hernandez, A
论文数: 0 引用数: 0
h-index: 0
机构: Univ Michigan, Sch Med, Dept Internal Med, Ctr Comprehens Canc, Ann Arbor, MI 48109 USA

Morrison, SJ
论文数: 0 引用数: 0
h-index: 0
机构: Univ Michigan, Sch Med, Dept Internal Med, Ctr Comprehens Canc, Ann Arbor, MI 48109 USA

Clarke, MF
论文数: 0 引用数: 0
h-index: 0
机构:
Univ Michigan, Sch Med, Dept Internal Med, Ctr Comprehens Canc, Ann Arbor, MI 48109 USA Univ Michigan, Sch Med, Dept Internal Med, Ctr Comprehens Canc, Ann Arbor, MI 48109 USA
[4]
Fra-1 regulates vimentin during Ha-RAS-induced epithelial mesenchymal transition in human colon carcinoma cells
[J].
Andreolas, Chrysovalantis
;
Kalogeropoulou, Margarita
;
Voulgari, Angeliki
;
Pintzas, Alexander
.
INTERNATIONAL JOURNAL OF CANCER,
2008, 122 (08)
:1745-1756

Andreolas, Chrysovalantis
论文数: 0 引用数: 0
h-index: 0
机构:
Natl Hellen Res Fdn, Inst Biol Res & Biotechnol, Lab Signal Mediated Gene Express, Athens 11635, Greece Natl Hellen Res Fdn, Inst Biol Res & Biotechnol, Lab Signal Mediated Gene Express, Athens 11635, Greece

Kalogeropoulou, Margarita
论文数: 0 引用数: 0
h-index: 0
机构:
Natl Hellen Res Fdn, Inst Biol Res & Biotechnol, Lab Signal Mediated Gene Express, Athens 11635, Greece Natl Hellen Res Fdn, Inst Biol Res & Biotechnol, Lab Signal Mediated Gene Express, Athens 11635, Greece

Voulgari, Angeliki
论文数: 0 引用数: 0
h-index: 0
机构:
Natl Hellen Res Fdn, Inst Biol Res & Biotechnol, Lab Signal Mediated Gene Express, Athens 11635, Greece Natl Hellen Res Fdn, Inst Biol Res & Biotechnol, Lab Signal Mediated Gene Express, Athens 11635, Greece

Pintzas, Alexander
论文数: 0 引用数: 0
h-index: 0
机构:
Natl Hellen Res Fdn, Inst Biol Res & Biotechnol, Lab Signal Mediated Gene Express, Athens 11635, Greece Natl Hellen Res Fdn, Inst Biol Res & Biotechnol, Lab Signal Mediated Gene Express, Athens 11635, Greece
[5]
Induction of EMT by twist proteins as a collateral effect of tumor-promoting inactivation of premature senescence
[J].
Ansieau, Stephane
;
Bastid, Jeremy
;
Doreau, Agnes
;
Morel, Anne-Pierre
;
Bouchet, Benjamin P.
;
Thomas, Clemence
;
Fauvet, Frederique
;
Puisieux, Isabelle
;
Doglioni, Claudio
;
Piccinin, Sara
;
Maestro, Roberta
;
Voeltzel, Thibault
;
Selmi, Abdelkader
;
Valsesia-Wittmann, Sandrine
;
de Fromentel, Claude Caron
;
Puisieux, Alain
.
CANCER CELL,
2008, 14 (01)
:79-89

Ansieau, Stephane
论文数: 0 引用数: 0
h-index: 0
机构:
INSERM, U590, F-69008 Lyon, France INSERM, U590, F-69008 Lyon, France

Bastid, Jeremy
论文数: 0 引用数: 0
h-index: 0
机构:
INSERM, U590, F-69008 Lyon, France
Univ Lyon 1, Inst Sci Pharmaceut & Biol, F-69008 Lyon, France INSERM, U590, F-69008 Lyon, France

Doreau, Agnes
论文数: 0 引用数: 0
h-index: 0
机构:
INSERM, U590, F-69008 Lyon, France INSERM, U590, F-69008 Lyon, France

Morel, Anne-Pierre
论文数: 0 引用数: 0
h-index: 0
机构:
Ctr Leon Berard, FNCLCC, Lab Rech Translat, F-69008 Lyon, France INSERM, U590, F-69008 Lyon, France

Bouchet, Benjamin P.
论文数: 0 引用数: 0
h-index: 0
机构:
INSERM, U590, F-69008 Lyon, France
Univ Lyon 1, Inst Sci Pharmaceut & Biol, F-69008 Lyon, France INSERM, U590, F-69008 Lyon, France

Thomas, Clemence
论文数: 0 引用数: 0
h-index: 0
机构:
INSERM, U590, F-69008 Lyon, France
Univ Lyon 1, Inst Sci Pharmaceut & Biol, F-69008 Lyon, France INSERM, U590, F-69008 Lyon, France

Fauvet, Frederique
论文数: 0 引用数: 0
h-index: 0
机构:
Ctr Leon Berard, FNCLCC, Lab Rech Translat, F-69008 Lyon, France INSERM, U590, F-69008 Lyon, France

Puisieux, Isabelle
论文数: 0 引用数: 0
h-index: 0
机构:
INSERM, U590, F-69008 Lyon, France INSERM, U590, F-69008 Lyon, France

Doglioni, Claudio
论文数: 0 引用数: 0
h-index: 0
机构:
Belluno City Hosp, I-32100 Belluno, Italy INSERM, U590, F-69008 Lyon, France

Piccinin, Sara
论文数: 0 引用数: 0
h-index: 0
机构:
Aviano Natl Canc Inst, CRO IRCCS, I-33081 Aviano, Italy INSERM, U590, F-69008 Lyon, France

Maestro, Roberta
论文数: 0 引用数: 0
h-index: 0
机构:
Aviano Natl Canc Inst, CRO IRCCS, I-33081 Aviano, Italy INSERM, U590, F-69008 Lyon, France

Voeltzel, Thibault
论文数: 0 引用数: 0
h-index: 0
机构:
INSERM, U590, F-69008 Lyon, France INSERM, U590, F-69008 Lyon, France

Selmi, Abdelkader
论文数: 0 引用数: 0
h-index: 0
机构:
INSERM, U590, F-69008 Lyon, France
Univ Lyon 1, Inst Sci Pharmaceut & Biol, F-69008 Lyon, France INSERM, U590, F-69008 Lyon, France

Valsesia-Wittmann, Sandrine
论文数: 0 引用数: 0
h-index: 0
机构:
INSERM, U590, F-69008 Lyon, France INSERM, U590, F-69008 Lyon, France

de Fromentel, Claude Caron
论文数: 0 引用数: 0
h-index: 0
机构:
INSERM, U590, F-69008 Lyon, France INSERM, U590, F-69008 Lyon, France

Puisieux, Alain
论文数: 0 引用数: 0
h-index: 0
机构:
INSERM, U590, F-69008 Lyon, France
Univ Lyon 1, Inst Sci Pharmaceut & Biol, F-69008 Lyon, France
Ctr Leon Berard, FNCLCC, Lab Rech Translat, F-69008 Lyon, France INSERM, U590, F-69008 Lyon, France
[6]
Mice lacking Smad3 show accelerated wound healing and an impaired local inflammatory response
[J].
Ashcroft, GS
;
Yang, X
;
Glick, AB
;
Weinstein, M
;
Letterio, JJ
;
Mizel, DE
;
Anzano, M
;
Greenwell-Wild, T
;
Wahl, SM
;
Deng, CX
;
Roberts, AB
.
NATURE CELL BIOLOGY,
1999, 1 (05)
:260-266

Ashcroft, GS
论文数: 0 引用数: 0
h-index: 0
机构: NCI, Lab Cell Regulat & Carcinogenesis, Bethesda, MD 20892 USA

Yang, X
论文数: 0 引用数: 0
h-index: 0
机构: NCI, Lab Cell Regulat & Carcinogenesis, Bethesda, MD 20892 USA

Glick, AB
论文数: 0 引用数: 0
h-index: 0
机构: NCI, Lab Cell Regulat & Carcinogenesis, Bethesda, MD 20892 USA

Weinstein, M
论文数: 0 引用数: 0
h-index: 0
机构: NCI, Lab Cell Regulat & Carcinogenesis, Bethesda, MD 20892 USA

Letterio, JJ
论文数: 0 引用数: 0
h-index: 0
机构: NCI, Lab Cell Regulat & Carcinogenesis, Bethesda, MD 20892 USA

Mizel, DE
论文数: 0 引用数: 0
h-index: 0
机构: NCI, Lab Cell Regulat & Carcinogenesis, Bethesda, MD 20892 USA

Anzano, M
论文数: 0 引用数: 0
h-index: 0
机构: NCI, Lab Cell Regulat & Carcinogenesis, Bethesda, MD 20892 USA

Greenwell-Wild, T
论文数: 0 引用数: 0
h-index: 0
机构: NCI, Lab Cell Regulat & Carcinogenesis, Bethesda, MD 20892 USA

Wahl, SM
论文数: 0 引用数: 0
h-index: 0
机构: NCI, Lab Cell Regulat & Carcinogenesis, Bethesda, MD 20892 USA

Deng, CX
论文数: 0 引用数: 0
h-index: 0
机构: NCI, Lab Cell Regulat & Carcinogenesis, Bethesda, MD 20892 USA

Roberts, AB
论文数: 0 引用数: 0
h-index: 0
机构: NCI, Lab Cell Regulat & Carcinogenesis, Bethesda, MD 20892 USA
[7]
Glycogen synthase kinase-3 is an endogenous inhibitor of snail transcription: implications for the epithelial-mesenchymal transition
[J].
Bachelder, RE
;
Yoon, SO
;
Franci, C
;
de Herreros, AG
;
Mercurio, AM
.
JOURNAL OF CELL BIOLOGY,
2005, 168 (01)
:29-33

Bachelder, RE
论文数: 0 引用数: 0
h-index: 0
机构:
Harvard Univ, Sch Med, Beth Israel Deaconess Med Ctr, Dept Pathol,Div Canc Biol & Angiogenesis, Boston, MA 02115 USA Harvard Univ, Sch Med, Beth Israel Deaconess Med Ctr, Dept Pathol,Div Canc Biol & Angiogenesis, Boston, MA 02115 USA

Yoon, SO
论文数: 0 引用数: 0
h-index: 0
机构: Harvard Univ, Sch Med, Beth Israel Deaconess Med Ctr, Dept Pathol,Div Canc Biol & Angiogenesis, Boston, MA 02115 USA

Franci, C
论文数: 0 引用数: 0
h-index: 0
机构: Harvard Univ, Sch Med, Beth Israel Deaconess Med Ctr, Dept Pathol,Div Canc Biol & Angiogenesis, Boston, MA 02115 USA

de Herreros, AG
论文数: 0 引用数: 0
h-index: 0
机构: Harvard Univ, Sch Med, Beth Israel Deaconess Med Ctr, Dept Pathol,Div Canc Biol & Angiogenesis, Boston, MA 02115 USA

Mercurio, AM
论文数: 0 引用数: 0
h-index: 0
机构: Harvard Univ, Sch Med, Beth Israel Deaconess Med Ctr, Dept Pathol,Div Canc Biol & Angiogenesis, Boston, MA 02115 USA
[8]
Smad4 is dispensable for normal pancreas development yet critical in progression and tumor biology of pancreas cancer
[J].
Bardeesy, Nabeel
;
Cheng, Kuang-hung
;
Berger, Justin H.
;
Chu, Gerald C.
;
Pahler, Jessica
;
Olson, Peter
;
Hezel, Aram F.
;
Horner, James
;
Lauwers, Gregory Y.
;
Hanahan, Douglas
;
DePinho, Ronald A.
.
GENES & DEVELOPMENT,
2006, 20 (22)
:3130-3146

Bardeesy, Nabeel
论文数: 0 引用数: 0
h-index: 0
机构:
Harvard Univ, Massachusetts Gen Hosp, Sch Med, Boston, MA 02115 USA Harvard Univ, Massachusetts Gen Hosp, Sch Med, Boston, MA 02115 USA

Cheng, Kuang-hung
论文数: 0 引用数: 0
h-index: 0
机构: Harvard Univ, Massachusetts Gen Hosp, Sch Med, Boston, MA 02115 USA

Berger, Justin H.
论文数: 0 引用数: 0
h-index: 0
机构: Harvard Univ, Massachusetts Gen Hosp, Sch Med, Boston, MA 02115 USA

Chu, Gerald C.
论文数: 0 引用数: 0
h-index: 0
机构: Harvard Univ, Massachusetts Gen Hosp, Sch Med, Boston, MA 02115 USA

Pahler, Jessica
论文数: 0 引用数: 0
h-index: 0
机构: Harvard Univ, Massachusetts Gen Hosp, Sch Med, Boston, MA 02115 USA

Olson, Peter
论文数: 0 引用数: 0
h-index: 0
机构: Harvard Univ, Massachusetts Gen Hosp, Sch Med, Boston, MA 02115 USA

Hezel, Aram F.
论文数: 0 引用数: 0
h-index: 0
机构: Harvard Univ, Massachusetts Gen Hosp, Sch Med, Boston, MA 02115 USA

Horner, James
论文数: 0 引用数: 0
h-index: 0
机构: Harvard Univ, Massachusetts Gen Hosp, Sch Med, Boston, MA 02115 USA

Lauwers, Gregory Y.
论文数: 0 引用数: 0
h-index: 0
机构: Harvard Univ, Massachusetts Gen Hosp, Sch Med, Boston, MA 02115 USA

Hanahan, Douglas
论文数: 0 引用数: 0
h-index: 0
机构: Harvard Univ, Massachusetts Gen Hosp, Sch Med, Boston, MA 02115 USA

DePinho, Ronald A.
论文数: 0 引用数: 0
h-index: 0
机构: Harvard Univ, Massachusetts Gen Hosp, Sch Med, Boston, MA 02115 USA
[9]
The transcription factor Snail is a repressor of E-cadherin gene expression in epithelial tumour cells
[J].
Batlle, E
;
Sancho, E
;
Franci, C
;
Domínguez, D
;
Monfar, M
;
Baulida, J
;
de Herreros, AG
.
NATURE CELL BIOLOGY,
2000, 2 (02)
:84-89

Batlle, E
论文数: 0 引用数: 0
h-index: 0
机构:
Univ Pompeu Fabra, Unitat Biol Cellular & Mol, Inst Municipal Invest Med, Barcelona 08003, Spain Univ Pompeu Fabra, Unitat Biol Cellular & Mol, Inst Municipal Invest Med, Barcelona 08003, Spain

Sancho, E
论文数: 0 引用数: 0
h-index: 0
机构:
Univ Pompeu Fabra, Unitat Biol Cellular & Mol, Inst Municipal Invest Med, Barcelona 08003, Spain Univ Pompeu Fabra, Unitat Biol Cellular & Mol, Inst Municipal Invest Med, Barcelona 08003, Spain

Franci, C
论文数: 0 引用数: 0
h-index: 0
机构:
Univ Pompeu Fabra, Unitat Biol Cellular & Mol, Inst Municipal Invest Med, Barcelona 08003, Spain Univ Pompeu Fabra, Unitat Biol Cellular & Mol, Inst Municipal Invest Med, Barcelona 08003, Spain

Domínguez, D
论文数: 0 引用数: 0
h-index: 0
机构:
Univ Pompeu Fabra, Unitat Biol Cellular & Mol, Inst Municipal Invest Med, Barcelona 08003, Spain Univ Pompeu Fabra, Unitat Biol Cellular & Mol, Inst Municipal Invest Med, Barcelona 08003, Spain

Monfar, M
论文数: 0 引用数: 0
h-index: 0
机构:
Univ Pompeu Fabra, Unitat Biol Cellular & Mol, Inst Municipal Invest Med, Barcelona 08003, Spain Univ Pompeu Fabra, Unitat Biol Cellular & Mol, Inst Municipal Invest Med, Barcelona 08003, Spain

Baulida, J
论文数: 0 引用数: 0
h-index: 0
机构:
Univ Pompeu Fabra, Unitat Biol Cellular & Mol, Inst Municipal Invest Med, Barcelona 08003, Spain Univ Pompeu Fabra, Unitat Biol Cellular & Mol, Inst Municipal Invest Med, Barcelona 08003, Spain

de Herreros, AG
论文数: 0 引用数: 0
h-index: 0
机构:
Univ Pompeu Fabra, Unitat Biol Cellular & Mol, Inst Municipal Invest Med, Barcelona 08003, Spain Univ Pompeu Fabra, Unitat Biol Cellular & Mol, Inst Municipal Invest Med, Barcelona 08003, Spain
[10]
The plasminogen activator inhibitor "paradox" in cancer
[J].
Binder, Bernd R.
;
Mihaly, Judit
.
IMMUNOLOGY LETTERS,
2008, 118 (02)
:116-124

Binder, Bernd R.
论文数: 0 引用数: 0
h-index: 0
机构:
Med Univ Vienna, Ctr Biomol Med & Pharmacol, Dept Vasc Biol & Thrombosis Res, A-1090 Vienna, Austria Med Univ Vienna, Ctr Biomol Med & Pharmacol, Dept Vasc Biol & Thrombosis Res, A-1090 Vienna, Austria

Mihaly, Judit
论文数: 0 引用数: 0
h-index: 0
机构:
Med Univ Vienna, Ctr Biomol Med & Pharmacol, Dept Vasc Biol & Thrombosis Res, A-1090 Vienna, Austria Med Univ Vienna, Ctr Biomol Med & Pharmacol, Dept Vasc Biol & Thrombosis Res, A-1090 Vienna, Austria