The renal type II Na+/phosphate cotransporter

被引：24
作者：
Biber, J [1 ]
Murer, H [1 ]
Forster, I [1 ]
机构：
[1] Univ Zurich, Inst Physiol, CH-8057 Zurich, Switzerland
来源：
JOURNAL OF BIOENERGETICS AND BIOMEMBRANES | 1998年 / 30卷 / 02期
关键词：
proximal tubule; transport; phosphate; regulation;
D O I：
10.1023/A:1020525409894
中图分类号：
Q6 [生物物理学];
学科分类号：
071011 ;
摘要：
A sodium-dependent phosphate transporter (type II Na/Pi-cotransporter) was isolated which is expressed in apical membranes of proximal tubules and exhibits transport characteristics similar as described for renal reabsorption of phosphate. Type II associated Na/Pi-cotransport is electrogenic and results obtained by electrophysiological measurements support a transport model having a stoichiometry of 3 Na+/HPO4=. Changes of transport such as by parathyroid hormone and altered dietary intake of phosphate correlate with changes of the number of type II cotransporters in the apical membrane. These data suggest that the type II Na/Pi-cotransporter represents the main target for physiological and pathophysiological regulation.
引用
收藏
页码：187 / 194
页数：8
相关论文
共 39 条
[1]   EFFECT OF PH ON PHOSPHATE-TRANSPORT IN RAT RENAL BRUSH-BORDER MEMBRANE-VESICLES [J].
AMSTUTZ, M ;
MOHRMANN, M ;
GMAJ, P ;
MURER, H .
AMERICAN JOURNAL OF PHYSIOLOGY, 1985, 248 (05) :F705-F710
[2]  
Berndt T., 1992, KIDNEY PHYSL PATHOPH, P2511
[3]   Renal Na/P-i-cotransporters [J].
Biber, J ;
Custer, M ;
Magagnin, S ;
Hayes, G ;
Werner, A ;
Lotscher, M ;
Kaissling, B ;
Murer, H .
KIDNEY INTERNATIONAL, 1996, 49 (04) :981-985
[4]  
BOYER CJ, 1996, BIOCHIM BIOPHYS ACTA, V128, P117
[5]  
BURKHARDT G, 1981, PFLUGERS ARCH, V390, P191
[6]   ELECTROPHYSIOLOGICAL ANALYSIS OF NA+/P-I COTRANSPORT MEDIATED BY A TRANSPORTER CLONED FROM RAT-KIDNEY AND EXPRESSED IN XENOPUS-OOCYTES [J].
BUSCH, A ;
WALDEGGER, S ;
HERZER, T ;
BIBER, J ;
MARKOVICH, D ;
HAYES, G ;
MURER, H ;
LANG, F .
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1994, 91 (17) :8205-8208
[7]  
Busch AE, 1995, J AM SOC NEPHROL, V6, P1547
[8]   Expression of a renal type I sodium/phosphate transporter (NaPi-1) induces a conductance in Xenopus oocytes permeable for organic and inorganic anions [J].
Busch, AE ;
Schuster, A ;
Waldegger, S ;
Wagner, CA ;
Zempel, G ;
Broer, S ;
Biber, J ;
Murer, H ;
Lang, F .
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1996, 93 (11) :5347-5351
[9]   RENAL ADAPTATION TO PHOSPHATE LOAD IN THE ACUTELY THYROPARATHYROIDECTOMIZED RAT - RAPID ALTERATION IN BRUSH-BORDER MEMBRANE PHOSPHATE-TRANSPORT [J].
CHENG, L ;
DERSCH, C ;
KRAUS, E ;
SPECTOR, D ;
SACKTOR, B .
AMERICAN JOURNAL OF PHYSIOLOGY, 1984, 246 (04) :F488-F494
[10]   MOLECULAR-CLONING, FUNCTIONAL EXPRESSION, TISSUE DISTRIBUTION, AND IN-SITU HYBRIDIZATION OF THE RENAL SODIUM-PHOSPHATE (NA+/P-I) TRANSPORTER IN THE CONTROL AND HYPOPHOSPHATEMIC MOUSE [J].
COLLINS, JF ;
GHISHAN, FK .
FASEB JOURNAL, 1994, 8 (11) :862-868
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