Distant metastases after definitive radiotherapy for squamous cell carcinoma of the head and neck

被引：36
|
作者：
Al-Othman, MOF [1 ]
Morris, CG [1 ]
Hinerman, RW [1 ]
Amdur, RJ [1 ]
Mendenhall, WM [1 ]
机构：
[1] Univ Florida, Coll Med, Dept Radiat Oncol, Gainesville, FL 32608 USA
来源：
HEAD AND NECK-JOURNAL FOR THE SCIENCES AND SPECIALTIES OF THE HEAD AND NECK | 2003年 / 25卷 / 08期
关键词：
head and neck; squamous cell carcinoma; distant metastases; radiotherapy; RADIATION-THERAPY; RANDOMIZED TRIAL; ALTERED FRACTIONATION; REGIONAL CONTROL; CANCER; CHEMOTHERAPY; IRRADIATION; HYPERFRACTIONATION; MANAGEMENT; FAILURE;
D O I：
10.1002/hed.10275
中图分类号：
R76 [耳鼻咽喉科学];
学科分类号：
100213 ;
摘要：
Purpose. To analyze parameters that influence the risk of distant metastases after definitive radiotherapy. Methods. Between 1983 and 1997, 873 patients were treated with definitive radiotherapy and had follow-up for 2 years or more. Univariate and multivariate analyses were performed to evaluate risk factors that might influence the risk of distant metastases. Results. The 5-year distant metastasis-free survival rate was 86%. Univariate analyses revealed that the risk of distant metastases was significantly influenced by gender (p =.0092), primary site (p=.0023), T stage (p<.0001), N stage (p<.0001), overall stage (p<.0001), level of nodal metastases in the neck (p<.0001), histologic differentiation (p =.0096), control above the clavicles (p<.0001), and time to locoregional recurrence (p<.0001). Multivariate analysis of freedom from distant metastases revealed that gender (p=.0390), T stage (p<.0001), N stage (p=.0060), nodal level (p<.0001), and locoregional control (p<.0001) significantly influenced this end point. Multivariate analysis revealed that gender (p=.0049), T stage (p<.0001), N stage (p<.0001), and locoregional control (p<.0001) significantly influenced cause-specific survival. Conclusions. The risk of distant metastases after definitive radiotherapy is 14% at 5 years and is significantly influenced by gender, T stage, N stage, nodal level, and locoregional control. (C) 2003 Wiley Periodicals, Inc.
引用
收藏
页码：629 / 633
页数：5
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