The Association of MMP9 Promoter Rs3918242 Genotype With Gastric Cancer

被引：25

作者：

Fu, Chun-Kai ^{[1
,2
,3
,4
]}

Chang, Wen-Shin ^{[1
]}

Tsai, Chia-Wen ^{[1
,3
]}

Wang, Yun-Chi ^{[1
,3
]}

Yang, Mei-Due ^{[3
]}

Hsu, Hua-Shai ^{[5
]}

Chao, Che-Yi ^{[6
]}

Yu, Chien-Chih ^{[3
]}

Chen, Jaw-Chyun ^{[7
]}

Pei, Jen-Sheng ^{[8
]}

Bau, Da-Tian ^{[1
,3
,9
]}

机构：

[1] China Med Univ, Grad Inst Biomed Sci, Taichung, Taiwan

[2] Taichung Armed Forces Gen Hosp, Taichung, Taiwan

[3] China Med Univ Hosp, Dept Med Res, Terry Fox Canc Res Lab, Taichung, Taiwan

[4] Natl Def Med Ctr, Taipei, Taiwan

[5] China Med Univ Hosp, Dept Med Imaging, Taichung, Taiwan

[6] Asia Univ, Dept Food Nutr & Hlth Biotechnol, Taichung, Taiwan

[7] Da Yeh Univ, Dept Med Bot & Hlth Applicat, Changhua, Taiwan

[8] Taoyuan Gen Hosp, Minist Hlth & Welf, Dept Pediat, Taoyuan, Taiwan

[9] Asia Univ, Dept Bioinformat & Med Engn, Taichung, Taiwan

来源：

ANTICANCER RESEARCH | 2021年 / 41卷 / 07期

关键词：

Gastric cancer; genotype; MMP9; polymorphism; Taiwan; LYMPH-NODE METASTASIS; MATRIX METALLOPROTEINASES; CHROMOSOMAL IMBALANCES; GENETIC ALTERATIONS; STOMACH-CANCER; BREAST-CANCER; UP-REGULATION; RISK-FACTORS; MATRIX-METALLOPROTEINASE-9; POLYMORPHISM;

D O I：

10.21873/anticanres.15118

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Background/Aim: Matrix metalloproteinase 9 (MMP9) is highly expressed in gastric cancer but the role of MMP9 is unclear. This study aimed at revealing the association of MMP9 promoter rs3918242 genotypes with gastric cancer risk. Materials and Methods: MMP9 rs3918242 genotypes of 121 patients with gastric cancer and 363 healthy individuals were examined by polymerase chain reaction-restriction fragment length polymorphism methodology using serum samples. Results: MMP9 rs3918242 TT genotype carriers had an elevated gastric cancer risk compared to wild-type CC carriers (odds ratio=3.92, 95% confidence interval=1.28-11.99; p=0.0103). Patients with CT/TT genotypes were at higher risk of metastasis (p=0.0178) than those with CC. No correlation was found between MMP9 rs3918242 genotype and gastric cancer risk with smoking or alcohol behavior, nor Helicobacter pylori infection. No correlation was observed for MMP9 rs3918242 genotypic distributions with age, gender, or body mass index. Conclusion: Carrying a T allele for MMP9 rs3918242 may be predictive for higher gastric cancer risk, and as a predictor for higher risk of metastasis.

引用

页码：3309 / 3315

页数：7

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