Diversity-oriented approach to spirocycles with indole moiety via Fischer indole cyclization, olefin metathesis and Suzuki-Miyaura cross-coupling reactions

被引：34

作者：

Kotha, Sambasivarao ^{[1
]}

Ali, Rashid ^{[1
]}

Srinivas, Venu ^{[1
]}

Krishna, Nimita G. ^{[1
]}

机构：

[1] Indian Inst Technol, Dept Chem, Bombay 400076, Maharashtra, India

来源：

TETRAHEDRON | 2015年 / 71卷 / 01期

关键词：

Spirocycles; Claisen rearrangement; Fischer indole cyclization; Ring-closing metathesis; Suzuki Miyaura cross-coupling; RING-CLOSING METATHESIS; CLAISEN REARRANGEMENT; NATURAL-PRODUCTS; ARYLBORONIC ACIDS; ONE-POT; ALKALOIDS; CATALYSTS; ROUTE; SPIRO; FUNCTIONALIZATION;

D O I：

10.1016/j.tet.2014.11.024

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A range of aryl substituted spirocycles containing the indole moiety have been assembled through Claisen rearrangement, Fischer indole cyclization, ring-closing metathesis and the Suzuki-Miyaura cross-coupling reactions. Some of these molecules contain either a spirocyclic system or an indeno[1,2-b] indole framework, which is present in diverse bioactive targets. Here, we have used simple and readily available starting materials to generate a library of spirocycles with an indole unit in their structures. (C) 2014 Elsevier Ltd. All rights reserved.

引用

页码：129 / 138

页数：10

共 22 条

[21] Increasing appendage diversity on 3,4-dihydro-3-oxo-2H-1,4-benzoxazines via Aphos-Pd(OAc)2-catalyzed Suzuki-Miyaura cross-coupling of aryl chlorides
Yu, Gongli
Zheng, Yu
Wu, Jinlong
Dai, Wei-Min
TETRAHEDRON, 2013, 69 (48) : 10488 - 10496
[22] Synthesis of nano-sized C3-symmetric 2,4,6-triphenyl-1,3,5-s-triazine and 1,3,5-triphenylbenzene derivatives via the trimerization followed by Suzuki-Miyaura cross-coupling or O-alkylation reactions and their biological evaluation
Kotha, Sambasivarao
Kashinath, Dhurke
Lopus, Manu
Panda, Dulal
INDIAN JOURNAL OF CHEMISTRY SECTION B-ORGANIC CHEMISTRY INCLUDING MEDICINAL CHEMISTRY, 2009, 48 (12): : 1766 - 1770

← 1 2 3 →