Caspases:: key players in programmed cell death

被引：421
作者：
Grütter, MG [1 ]
机构：
[1] Univ Zurich, Inst Biochem, CH-8057 Zurich, Switzerland
来源：
CURRENT OPINION IN STRUCTURAL BIOLOGY | 2000年 / 10卷 / 06期
关键词：
D O I：
10.1016/S0959-440X(00)00146-9
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Research in apoptosis has established a central role for caspases. The recent determination of structures of caspase-1, caspase-3 and caspase-8, together with biochemical studies, has greatly enhanced our understanding of the structure, function and specificity of these enzymes. This provides a basis for the further elucidation of the biological role of caspases and a guide to the design of selective inhibitors to treat caspase-mediated diseases.
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页码：649 / 655
页数：7
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