A highly selective fluorescent nanoprobe based on AIE and ESIPT for imaging hydrogen sulfide in live cells and zebrafish

被引：159

作者：

Zhang, Peisheng ^{[1
,2
]}

Nie, Xuezheng ^{[1
]}

Gao, Meng ^{[1
]}

Zeng, Fang ^{[1
]}

Qin, Anjun ^{[1
]}

Wu, Shuizhu ^{[1
]}

Tang, Ben Zhong ^{[1
]}

机构：

[1] South China Univ Technol, State Key Lab Luminescent Mat & Devices, Coll Mat Sci & Engn, Guangzhou 510640, Guangdong, Peoples R China

[2] Hunan Univ Sci & Technol, Key Lab Theoret Organ Chem & Funct Mol,Minist Edu, Hunan Prov Key Lab Controllable Preparat & Funct, Sch Chem & Chem Engn,Key Lab QSAR QSPR,Hunan Prov, Xiangtan 411201, Hunan, Peoples R China

来源：

MATERIALS CHEMISTRY FRONTIERS | 2017年 / 1卷 / 05期

关键词：

AGGREGATION-INDUCED EMISSION; TRANSPEPTIDASE-DEFICIENT MICE; LIGHT-UP PROBE; TURN-ON PROBE; LIVING CELLS; IN-VIVO; RATIOMETRIC DETECTION; AQUEOUS-SOLUTION; ENERGY-TRANSFER; H2S;

D O I：

10.1039/c6qm00223d

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

The rational design of effective tools capable of monitoring hydrogen sulfide (H2S) is of great importance to fully understand its physiological and pathological functions. Herein, a self-assembled fluorescent nanoprobe with both aggregation-induced emission (AIE) and excited-state intramolecular proton transfer (ESIPT) characteristics for H2S detection has been successfully developed via a modified nanoprecipitation method. The nanoprobe features high water dispersibility, a large Stokes shift (ca. 100 nm), good biocompatibility as well as high selectivity towards H2S over other putative interferents. Live cell imaging experiments demonstrate that the nanoprobe, with good cell-membrane permeability, can facilitate the visualization of exogenous and endogenous H2S levels. Moreover, the nanoprobe has also been found capable of detecting H2S in zebrafish. This nanoprobe with AIE and ESIPT characteristics can provide a novel method for the development of fluorescent probes for monitoring biological processes.

引用

页码：838 / 845

页数：8

共 79 条

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