Regulation of the cold-sensing TRPM8 channels by phosphoinositides and Gq-coupled receptors

被引：12
|
作者：
Liu, Luyu [1 ]
Rohacs, Tibor [1 ]
机构：
[1] Rutgers New Jersey Med Sch, Dept Pharmacol Physiol & Neurosci, Newark, NJ 07103 USA
来源：
CHANNELS | 2020年 / 14卷 / 01期
关键词：
TRPM8; PIP2; phosphoinositides; GPCR; G-alpha-q; PHOSPHOLIPASE-C; SENSOR TRPM8; MENTHOL; DESENSITIZATION; SENSITIVITY; INHIBITION; G-ALPHA(Q); MECHANISM;
D O I：
10.1080/19336950.2020.1734266
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
The Transient Receptor Potential Melastatin 8 (TRPM8) ion channel is an important sensor of environmental cold temperatures. Cold- and menthol-induced activation of this channel requires the presence of the membrane phospholipid phosphatidylinositol 4,5-bisphosphate [PI(4,5)P-2]. This review discusses recent findings on the role of PI(4,5)P-2 and G-proteins in the modulation of TRPM8 upon receptor activation. We will also summarize knowledge on the role of PI(4,5)P-2 in Ca2+ dependent desensitization/adaptation of TRPM8 activity, and recent advances in the structural basis of how this lipid binds to TRPM8.
引用
收藏
页码：79 / 86
页数：8
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