Regulation of the cold-sensing TRPM8 channels by phosphoinositides and Gq-coupled receptors

被引：12

作者：

Liu, Luyu ^{[1
]}

Rohacs, Tibor ^{[1
]}

机构：

[1] Rutgers New Jersey Med Sch, Dept Pharmacol Physiol & Neurosci, Newark, NJ 07103 USA

来源：

CHANNELS | 2020年 / 14卷 / 01期

关键词：

TRPM8; PIP2; phosphoinositides; GPCR; G-alpha-q; PHOSPHOLIPASE-C; SENSOR TRPM8; MENTHOL; DESENSITIZATION; SENSITIVITY; INHIBITION; G-ALPHA(Q); MECHANISM;

D O I：

10.1080/19336950.2020.1734266

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The Transient Receptor Potential Melastatin 8 (TRPM8) ion channel is an important sensor of environmental cold temperatures. Cold- and menthol-induced activation of this channel requires the presence of the membrane phospholipid phosphatidylinositol 4,5-bisphosphate [PI(4,5)P-2]. This review discusses recent findings on the role of PI(4,5)P-2 and G-proteins in the modulation of TRPM8 upon receptor activation. We will also summarize knowledge on the role of PI(4,5)P-2 in Ca2+ dependent desensitization/adaptation of TRPM8 activity, and recent advances in the structural basis of how this lipid binds to TRPM8.

引用

页码：79 / 86

页数：8

共 33 条

[31] Human TRPM8 and TRPAI pain channels including a gene variant with increased sensitivity to agonists (TRPA1 R797T), exhibit differential regulation by SRC-tyrosine kinase inhibitor
Morgan, Kevin
Sadofsky, Laura R.
Crow, Christopher
Morice, Alyn H.
BIOSCIENCE REPORTS, 2014, 34 : 469 - U226
[32] Agonist-induced Localization of Gq-coupled Receptors and G Protein-gated Inwardly Rectifying K+ (GIRK) Channels to Caveolae Determines Receptor Specificity of Phosphatidylinositol 4,5-Bisphosphate Signaling
Cui, Shanyu
Ho, Won-Kyung
Kim, Seong-Tae
Cho, Hana
JOURNAL OF BIOLOGICAL CHEMISTRY, 2010, 285 (53) : 41732 - 41739
[33] Topical application of TRPM8 agonists accelerates skin permeability barrier recovery and reduces epidermal proliferation induced by barrier insult: role of cold-sensitive TRP receptors in epidermal permeability barrier homoeostasis
Denda, Mitsuhiro
Tsutsumi, Moe
Denda, Sumiko
EXPERIMENTAL DERMATOLOGY, 2010, 19 (09) : 791 - 795

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