Regulation of the cold-sensing TRPM8 channels by phosphoinositides and Gq-coupled receptors

被引：12
|
作者：
Liu, Luyu [1 ]
Rohacs, Tibor [1 ]
机构：
[1] Rutgers New Jersey Med Sch, Dept Pharmacol Physiol & Neurosci, Newark, NJ 07103 USA
来源：
CHANNELS | 2020年 / 14卷 / 01期
关键词：
TRPM8; PIP2; phosphoinositides; GPCR; G-alpha-q; PHOSPHOLIPASE-C; SENSOR TRPM8; MENTHOL; DESENSITIZATION; SENSITIVITY; INHIBITION; G-ALPHA(Q); MECHANISM;
D O I：
10.1080/19336950.2020.1734266
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
The Transient Receptor Potential Melastatin 8 (TRPM8) ion channel is an important sensor of environmental cold temperatures. Cold- and menthol-induced activation of this channel requires the presence of the membrane phospholipid phosphatidylinositol 4,5-bisphosphate [PI(4,5)P-2]. This review discusses recent findings on the role of PI(4,5)P-2 and G-proteins in the modulation of TRPM8 upon receptor activation. We will also summarize knowledge on the role of PI(4,5)P-2 in Ca2+ dependent desensitization/adaptation of TRPM8 activity, and recent advances in the structural basis of how this lipid binds to TRPM8.
引用
收藏
页码：79 / 86
页数：8
相关论文
共 50 条
  • [21] Understanding the evolution of cold sensing and menthol activation in TRPM8
    Ramesh, Nikhil
    Luu, Dustin
    Shah, Karan H.
    Kazan, I. Can
    Ozkan, S. Banu
    Van Horn, Wade D.
    BIOPHYSICAL JOURNAL, 2023, 122 (03) : 197A - 197A
  • [22] Phosphoinositide Regulation of TRPM8 Channels in Planar Lipid Bilayers
    Zakharian, Eleonora
    Rohacs, Tibor
    BIOPHYSICAL JOURNAL, 2010, 98 (03) : 227A - 228A
  • [23] Cold-sensing TRPM8-neurons represent a cellular pathway for itch inhibition
    Palkar, R.
    McKemy, D.
    MOLECULAR BIOLOGY OF THE CELL, 2015, 26
  • [24] Ligand-stereoselective allosteric activation of cold-sensing TRPM8 channels by an H-bonded homochiral menthol dimer with head-to-head or head-to-tail
    Wang, Guangyu
    CHIRALITY, 2021, 33 (11) : 783 - 796
  • [25] TRPM8 in the negative regulation of TNFα expression during cold stress
    Wang, Xin-Pei
    Yu, Xuan
    Yan, Xiao-Jin
    Lei, Fan
    Chai, Yu-Shuang
    Jiang, Jing-Fei
    Yuan, Zhi-Yi
    Xing, Dong-Ming
    Du, Li-Jun
    SCIENTIFIC REPORTS, 2017, 7
  • [26] TRPM8 in the negative regulation of TNFα expression during cold stress
    Xin-Pei Wang
    Xuan Yu
    Xiao-Jin Yan
    Fan Lei
    Yu-Shuang Chai
    Jing-Fei Jiang
    Zhi-Yi Yuan
    Dong-Ming Xing
    Li-Jun Du
    Scientific Reports, 7
  • [27] Biophysical properties of menthol-activated cold receptor TRPM8 channels
    Hui, KY
    Guo, YB
    Feng, ZP
    BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 2005, 333 (02) : 374 - 382
  • [28] Mutations of TRPM8 channels: Unraveling the molecular basis of activation by cold and ligands
    Plaza-Cayon, Alejandro
    Gonzalez-Muniz, Rosario
    Martin-Martinez, Mercedes
    MEDICINAL RESEARCH REVIEWS, 2022, 42 (06) : 2168 - 2203
  • [29] Human neuroendocrine tumor cells express cold sensitive TRPM8 channels
    Mergler, S
    Plath, T
    Groetzinger, C
    Kaiser, S
    Neuhaus, P
    Bechstein, WO
    Wiedenmann, B
    GASTROENTEROLOGY, 2004, 126 (04) : A245 - A245
  • [30] Inhibition of TRPM8 Channels Reduces Pain in the Cold Pressor Test in Humans
    Winchester, Wendy J.
    Gore, Katrina
    Glatt, Sophie
    Petit, Wendy
    Gardiner, Jennifer C.
    Conlon, Kelly
    Postlethwaite, Michael
    Saintot, Pierre-Philippe
    Roberts, Sonia
    Gosset, James R.
    Matsuura, Tomomi
    Andrews, Mark D.
    Glossop, Paul A.
    Palmer, Michael J.
    Clear, Nicola
    Collins, Susie
    Beaumont, Kevin
    Reynolds, David S.
    JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS, 2014, 351 (02): : 259 - 269
12345