Progresses in Total Synthesis of Galantamine

被引：0
作者：
Fang, Lei [1 ,2 ]
Gou, Shaohua [1 ,2 ]
Zhang, Yihua [3 ]
机构：
[1] Southeast Univ, Sch Chem & Chem Engn, Pharmaceut Res Ctr, Nanjing 210009, Peoples R China
[2] Jiangsu Prov Hitech Key Lab Biomed Res, Lianyungang 222000, Peoples R China
[3] China Pharmaceut Univ, Ctr Drug Discovery, Nanjing 210009, Peoples R China
来源：
CHINESE JOURNAL OF ORGANIC CHEMISTRY | 2011年 / 31卷 / 03期
关键词：
galantamine; total synthesis; progress; EFFICIENT TOTAL-SYNTHESIS; ASYMMETRIC-SYNTHESIS; GALANTHAMINE; (+/-)-GALANTHAMINE; (-)-GALANTHAMINE; BIOSYNTHESIS; TRANSFORMATION; RESOLUTION; NARWEDINE; REAGENT;
D O I：
暂无
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
Galantamine, a natural alkaloid possessing AChE inhibitory and neuronal nicotinic receptor allosteric modulating effect, is widely used in clinic. Up to date, several different synthetic strategies have been developed for the total synthesis of galantamine, including the phenolic oxidative coupling reaction, the intramolecular Heck reaction, and so on. In this review, the recent progresses in the total synthesis of galantamine are reviewed. Furthermore, the evolution and the features of the existing strategies are also discussed.
引用
收藏
页码：286 / 296
页数：11
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