Preparation and characterization of highly stable lipid nanoparticles with amorphous core of tuneable viscosity

被引：71

作者：

Delmas, Thomas ^{[1
]}

Couffin, Anne-Claude ^{[1
]}

Bayle, Pierre Alain ^{[2
]}

de Crecy, Francois ^{[3
]}

Neumann, Emmanuelle ^{[4
]}

Vinet, Francoise ^{[1
]}

Bardet, Michel ^{[2
]}

Bibette, Jerome ^{[5
]}

Texier, Isabelle ^{[1
]}

机构：

[1] CEA, LETI, DTBS, MINATEC, F-38054 Grenoble 9, France

[2] CEA, INAC, SCIB, Lab Resonances Magnet, F-38054 Grenoble 9, France

[3] CEA, LETI, Dept Technol, MINATEC, F-38054 Grenoble 9, France

[4] CEA, IBS JP Ebel, CNRS, UJF,UMR 5075, F-38027 Grenoble 1, France

[5] ESPCI, Lab Calloides & Mat Divises, F-75231 Paris 5, France

来源：

JOURNAL OF COLLOID AND INTERFACE SCIENCE | 2011年 / 360卷 / 02期

关键词：

Lipid nanoparticle; Amorphous system; Physical stability; Design of experiments; CONTROLLED DRUG-DELIVERY; OF-THE-ART; VISCOELASTIC PROPERTIES; TOPICAL APPLICATION; SLN; NMR; CRYSTALLIZATION; STABILITY; CARRIERS; STATE;

D O I：

10.1016/j.jcis.2011.04.080

中图分类号：

O64 [物理化学（理论化学）、化学物理学];

学科分类号：

070304 ; 081704 ;

摘要：

Lipid nanoparticles (LNP) have been designed based on low cost and human-use approved excipients, and manufactured by an easy, robust, and up-scalable process. Fluid colloidal dispersions or gel viscous formulations of highly stable nanoparticles (more than 12 month stability is achieved for some formulations) can be obtained. Their physicochemical properties are studied by Dynamic Light Scattering, Differential Scanning Calorimetry, and NMR. The results picture nanoparticles with a non-crystalline core, which viscosity can be finely tuned by the lipid composition and the temperature. A design of experiments has been used to investigate the limits of the system colloidal stability. The impact of core and surfactant weight fractions have been explored both experimentally and using the design of experiments. The versatility of this physicochemical system could open the way to a wide range of future pharmaceutical applications. (C) 2011 Elsevier Inc. All rights reserved.

引用

页码：471 / 481

页数：11

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