In situ hybridization of PNA/DNA studied label-free by electrochemical impedance spectroscopy

被引：85
|
作者：
Liu, JY
Tian, SJ
Nielsen, PE
Knoll, W
机构：
[1] Max Planck Inst Polymer Res, D-55128 Mainz, Germany
[2] Univ Copenhagen, Panum Inst, Ctr Biochem Recognit, Dept Biochem & Genet,Biochem Lab B, DK-2200 Copenhagen, Denmark
来源：
CHEMICAL COMMUNICATIONS | 2005年 / 23期
关键词：
D O I：
10.1039/b419425j
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
The in situ hybridization kinetics of label-free DNA on mixed monolayers of peptide nucleic acid (PNA) and 6-mercapto-1-hexanol (MCH) on Au electrodes was investigated by electrochemical impedance spectroscopy (EIS) and used to discriminate the fully complementary DNA from the single-base mismatched hybrids.
引用
收藏
页码：2969 / 2971
页数：3
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