Role of Tissue Factor in Venous Thrombosis

被引：99
作者：
Manly, David A. [1 ]
Boles, Jeremiah [2 ]
Mackman, Nigel [2 ]
机构：
[1] E Carolina Univ, Brody Sch Med, Greenville, NC 27834 USA
[2] Univ N Carolina, Dept Med, Div Hematol Oncol, Chapel Hill, NC 27599 USA
来源：
ANNUAL REVIEW OF PHYSIOLOGY, VOL 73 | 2011年 / 73卷
关键词：
coagulation; microparticles; CELL-DERIVED MICROPARTICLES; FACTOR-POSITIVE MICROPARTICLES; ESCHERICHIA-COLI SEPSIS; HUMAN-ENDOTHELIAL-CELLS; DEEP-VEIN THROMBOSIS; FORMATION IN-VIVO; FACTOR EXPRESSION; P-SELECTIN; PULMONARY-EMBOLISM; PANCREATIC-CANCER;
D O I：
10.1146/annurev-physiol-042210-121137
中图分类号：
Q4 [生理学];
学科分类号：
071003 ;
摘要：
Venous thromboembolism (VTE) is a leading cause of morbidity and mortality worldwide. However, the mechanisms by which clots are formed in the deep veins have not been determined. Tissue factor (TF) is the primary initiator of the coagulation cascade and is essential for hemostasis. Under pathological conditions, TF is released into the circulation on small-membrane vesicles termed microparticles (MPs). Recent studies suggest that elevated levels of MP TF may trigger thrombosis. This review provides an overview of the role of TF in VTE.
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收藏
页码：515 / 525
页数：11
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