The Potential Use of Aptamers in The Process of Drug Development

被引：2

作者：

Gholikhani, Tooba ^{[1
,2
,3
]}

Brito, Balam Jimenez ^{[4
]}

Livingston, Frey ^{[4
]}

Kumar, Shalen ^{[5
]}

机构：

[1] Tabriz Univ Med Sci, Student Res Comm, Tabriz, Iran

[2] Tabriz Univ Med Sci, Fac Pharm, Tabriz, Iran

[3] Nanora Pharmaceut, Tabriz, Iran

[4] Victoria Univ Wellington New Zealand, Sch Biol Sci, Wellington, New Zealand

[5] IQ Sci Ltd, Wellington, New Zealand

来源：

PHARMACEUTICAL SCIENCES | 2021年 / 27卷 / 04期

关键词：

Aptamers; Drug discovery; Drug development; SELEX; NUCLEIC-ACID APTAMERS; SYSTEMATIC EVOLUTION; GENERATION; THERAPEUTICS; ANTIBODIES; MOLECULES; SELECTION; LIGANDS; GROWTH; ASSAY;

D O I：

10.34172/PS.2021.17

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

Single-stranded nucleic acids can fold and create unique 3-dimensional structures when interacting with other molecules. The unique structure can achieve high specificity and affinity for the particular target. Synthetic oligonucleotide binding agents, also known as aptamers, are generated through the rational process of Systematic Evolution of Ligands by Exponential Enrichment (SELEX). As this technology matures, it shows increasing promise for use in the field of therapeutic drugs, drug discovery, development, and delivery, and this report seeks to detail how this technology may be applied.

引用

页码：503 / 510

页数：8

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