DARPP-32 and NCS-1 expression is not altered in brains of rats treated with typical or atypical antipsychotics

被引：24

作者：

Souza, Bruno R. ^{[1
]}

Motta, Bernardo S. ^{[1
]}

Rosa, Daniela V. F. ^{[1
]}

Torres, Karen C.L. ^{[1
]}

Castro, Adalberto A. ^{[2
]}

Comim, Clarissa M. ^{[2
]}

Sampaio, Andre M. ^{[1
]}

Lima, Fabricio F. ^{[1
]}

Jeromin, Andreas ^{[3
]}

Quevedo, Joao ^{[2
]}

Romano-Silva, Marco A. ^{[1
,4
]}

机构：

[1] Univ Fed Minas Gerais, Fac Med, Dept Saude Mental, Neurociencias Lab, BR-30130100 Belo Horizonte, MG, Brazil

[2] Univ Extremo Sul Catarinense, Programa Pos Graduacao Ciencias Saude, Neurociencias Lab, BR-88806000 Criciuma, SC, Brazil

[3] Univ Texas, Ctr Learning & Memory, Austin, TX USA

[4] Univ Fed Minas Gerais, Inst Ciencias Biol, Dept Farmacol, BR-31270901 Belo Horizonte, MG, Brazil

来源：

NEUROCHEMICAL RESEARCH | 2008年 / 33卷 / 03期

关键词：

DARPP-32; NCS-1; antipsychotic; schizophrenia;

D O I：

10.1007/s11064-007-9470-2

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Dopamine-mediated neurotransmission imbalances are associated with several psychiatry illnesses, such as schizophrenia. Recently it was demonstrated that two proteins involved in dopamine signaling are altered in prefrontal cortex (PFC) of schizophrenic patients. DARPP-32 is a key downstream effector of intracellular signaling pathway and is downregulated in PFC of schizophrenic subjects. NCS-1 is a neuronal calcium sensor that can inhibit dopamine receptor D-2 internalization and is upregulated in PFC of schizophrenic subjects. It is well known that dopamine D-2 receptor is the main target of antipsychotic. Therefore, our purpose was to study if chronic treatment with typical or atypical antipsychotics induced alterations in DARPP-32 and NCS-1 expression in five brain regions: prefrontal cortex, hippocampus, striatum, cortex and cerebellum. We did not find any changes in DARPP-32 and NCS-1 protein expression in any brain region investigated.

引用

页码：533 / 538

页数：6

共 4 条

[1] DARPP-32 and NCS-1 Expression is not Altered in Brains of Rats Treated with Typical or Atypical Antipsychotics
Bruno R. Souza
Bernardo S. Motta
Daniela V. F. Rosa
Karen C. L. Torres
Adalberto A. Castro
Clarissa M. Comim
André M. Sampaio
Fabrício F. Lima
Andreas Jeromin
João Quevedo
Marco A. Romano-Silva
Neurochemical Research, 2008, 33 : 533 - 538
[2] Altered DARPP-32 expression in the superior temporal gyrus in schizophrenia
Kunii, Yasuto
Yabe, Hirooki
Wada, Akira
Yang, Qiaohui
Nishiura, Keisuke
Niwa, Shin-ichi
PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY, 2011, 35 (04) : 1139 - 1143
[3] Detailed DARPP-32 expression profiles in postmortem brains from patients with schizophrenia: an immunohistochemical study
Yasuto Kunii
Keiko Ikemoto
Akira Wada
Qiaohui Yang
Takashi Kusakabe
Toshimitsu Suzuki
Shin-ichi Niwa
Medical Molecular Morphology, 2011, 44 : 190 - 199
[4] Detailed DARPP-32 expression profiles in postmortem brains from patients with schizophrenia: an immunohistochemical study
Kunii, Yasuto
Ikemoto, Keiko
Wada, Akira
Yang, Qiaohui
Kusakabe, Takashi
Suzuki, Toshimitsu
Niwa, Shin-ichi
MEDICAL MOLECULAR MORPHOLOGY, 2011, 44 (04) : 190 - 199

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