Regioselectivity-Switchable Hydroarylation of Styrenes

被引：204

作者：

Gao, Ke ^{[1
]}

Yoshikai, Naohiko ^{[1
]}

机构：

[1] Nanyang Technol Univ, Sch Phys & Math Sci, Div Chem & Biol Chem, Singapore 637371, Singapore

来源：

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY | 2011年 / 133卷 / 03期

基金：

新加坡国家研究基金会;

关键词：

C-H BOND; CARBON-HYDROGEN BONDS; CATALYZED HYDROARYLATION; ALKYL-HALIDES; DIMETHYLPHENYLSILYLMETHYLMAGNESIUM CHLORIDE; INTERMOLECULAR HYDROARYLATION; ACTIVATION; EFFICIENT; OLEFINS; ALKENES;

D O I：

10.1021/ja108809u

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Cobalt phosphine and cobalt carbene catalysts have been developed for the hydroarylation of styrenes via chelation-assisted C-H bond activation, to afford branched and linear addition products, respectively, in a highly regioselective fashion. Deuterium-labeling experiments suggested a mechanism involving reversible C-H bond cleavage and olefin insertion steps and reductive elimination as the rate-and regioselectivity-determining step.

引用

页码：400 / 402

页数：3

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