The actin cytoskeleton: a key regulator of apoptosis and ageing?

被引：331
|
作者：
Gourlay, CW [1 ]
Ayscough, KR [1 ]
机构：
[1] Univ Sheffield, Dept Mol Biol & Biotechnol, Sheffield S10 2TN, S Yorkshire, England
来源：
NATURE REVIEWS MOLECULAR CELL BIOLOGY | 2005年 / 6卷 / 07期
基金：
英国医学研究理事会;
关键词：
D O I：
10.1038/nrm1682
中图分类号：
Q2 [细胞生物学];
学科分类号：
071009 ; 090102 ;
摘要：
Evidence from many organisms has shown that the accumulation of reactive oxygen species (ROS) has a detrimental effect on cell well-being. High levels of ROS have been linked to programmed cell death pathways and to ageing. Recent reports have implicated changes to the dynamics of the actin cytoskeleton in the release of ROS from mitochondria and subsequent cell death.
引用
收藏
页码：583 / U5
页数：8
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