The actin cytoskeleton: a key regulator of apoptosis and ageing?

被引：331
|
作者：
Gourlay, CW [1 ]
Ayscough, KR [1 ]
机构：
[1] Univ Sheffield, Dept Mol Biol & Biotechnol, Sheffield S10 2TN, S Yorkshire, England
来源：
NATURE REVIEWS MOLECULAR CELL BIOLOGY | 2005年 / 6卷 / 07期
基金：
英国医学研究理事会;
关键词：
D O I：
10.1038/nrm1682
中图分类号：
Q2 [细胞生物学];
学科分类号：
071009 ; 090102 ;
摘要：
Evidence from many organisms has shown that the accumulation of reactive oxygen species (ROS) has a detrimental effect on cell well-being. High levels of ROS have been linked to programmed cell death pathways and to ageing. Recent reports have implicated changes to the dynamics of the actin cytoskeleton in the release of ROS from mitochondria and subsequent cell death.
引用
收藏
页码：583 / U5
页数：8
相关论文
共 50 条
  • [1] The actin cytoskeleton: a key regulator of apoptosis and ageing?
    Campbell W. Gourlay
    Kathryn R. Ayscough
    Nature Reviews Molecular Cell Biology, 2005, 6 : 583 - 589
  • [2] The actin cytoskeleton in ageing and apoptosis
    Gourlay, CW
    Ayscough, KR
    FEMS YEAST RESEARCH, 2005, 5 (12) : 1193 - 1198
  • [3] CYTOSKELETON Actin regulator substitution
    Hutchinson, Ezzie
    NATURE REVIEWS MOLECULAR CELL BIOLOGY, 2012, 13 (10) : 606 - 606
  • [4] The Actin Cytoskeleton as a Regulator of Proteoglycan 4
    Gonzalez-Nolde, Sofia
    Schweiger, Cameron J.
    Davis, Elizabeth E. R.
    Manzoni, Thomas J.
    Hussein, Samer M. I.
    Schmidt, Tannin A.
    Cone, Stephanie G.
    Jay, Gregory D.
    Parreno, Justin
    CARTILAGE, 2024,
  • [5] Apoptosis and the yeast actin cytoskeleton
    Leadsham, J. E.
    Kotiadis, V. N.
    Tarrant, D. J.
    Gourlay, C. W.
    CELL DEATH AND DIFFERENTIATION, 2010, 17 (05): : 754 - 762
  • [6] Apoptosis and the yeast actin cytoskeleton
    J E Leadsham
    V N Kotiadis
    D J Tarrant
    C W Gourlay
    Cell Death & Differentiation, 2010, 17 : 754 - 762
  • [7] Apoptosis in platelets is independent of the actin cytoskeleton
    De Silva, Enoli
    Paul, Manoj
    Kim, Hugh
    PLOS ONE, 2022, 17 (11):
  • [8] Mechanistic and inhibition studies of the Arp2/3 complex, a key regulator of the actin cytoskeleton
    Patargias, George
    Magriotis, Plato A.
    Panagiotou, Maria
    Hetrick, Byron
    Han, Julianna
    Montgomery, Mike
    Baggett, Andrew
    Han, Min S.
    Glass, Adam C.
    Liu, Shih Y.
    Nolen, Brad J.
    Cournia, Zoe
    ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY, 2014, 247
  • [9] Tropomyosin - master regulator of actin filament function in the cytoskeleton
    Gunning, Peter W.
    Hardeman, Edna C.
    Lappalainen, Pekka
    Mulvihill, Daniel P.
    JOURNAL OF CELL SCIENCE, 2015, 128 (16) : 2965 - 2974
  • [10] nArgBP2: a brain regulator of the actin cytoskeleton
    Cestra, G
    Chang, S
    Nemoto, Y
    De Camilli, P
    MOLECULAR BIOLOGY OF THE CELL, 2002, 13 : 56A - 57A
12345