The actin cytoskeleton: a key regulator of apoptosis and ageing?

被引：331
作者：
Gourlay, CW [1 ]
Ayscough, KR [1 ]
机构：
[1] Univ Sheffield, Dept Mol Biol & Biotechnol, Sheffield S10 2TN, S Yorkshire, England
来源：
NATURE REVIEWS MOLECULAR CELL BIOLOGY | 2005年 / 6卷 / 07期
基金：
英国医学研究理事会;
关键词：
D O I：
10.1038/nrm1682
中图分类号：
Q2 [细胞生物学];
学科分类号：
071009 ; 090102 ;
摘要：
Evidence from many organisms has shown that the accumulation of reactive oxygen species (ROS) has a detrimental effect on cell well-being. High levels of ROS have been linked to programmed cell death pathways and to ageing. Recent reports have implicated changes to the dynamics of the actin cytoskeleton in the release of ROS from mitochondria and subsequent cell death.
引用
收藏
页码：583 / U5
页数：8
相关论文
共 52 条
  • [1] ADF/cofilin mediates actin cytoskeletal alterations in LLC-PK cells during ATP depletion
    Ashworth, SL
    Southgate, EL
    Sandoval, RM
    Meberg, PJ
    Bamburg, JR
    Molitoris, BA
    [J]. AMERICAN JOURNAL OF PHYSIOLOGY-RENAL PHYSIOLOGY, 2003, 284 (04) : F852 - F862
  • [2] Mechanism of actin polymerization in cellular ATP depletion
    Atkinson, SJ
    Hosford, MA
    Molitoris, BA
    [J]. JOURNAL OF BIOLOGICAL CHEMISTRY, 2004, 279 (07) : 5194 - 5199
  • [3] Actin: General principles from studies in yeast
    Ayscough, KR
    Drubin, DG
    [J]. ANNUAL REVIEW OF CELL AND DEVELOPMENTAL BIOLOGY, 1996, 12 : 129 - 160
  • [4] ADF/cofilin and actin dynamics in disease
    Bamburg, JR
    Wiggan, OP
    [J]. TRENDS IN CELL BIOLOGY, 2002, 12 (12) : 598 - 605
  • [5] Bernstein BW, 2003, J NEUROSCI, V23, P1
  • [6] Expression and cytogenetic localization of the human SM22 gene (TAGLN)
    Camoretti-Mercado, B
    Forsythe, SM
    LeBeau, MM
    Espinosa, R
    Vieira, JE
    Halayko, AJ
    Willadsen, S
    Kurtz, B
    Ober, C
    Evans, GA
    Thweatt, R
    Shapiro, S
    Niu, Q
    Qin, YM
    Padrid, PA
    Solway, J
    [J]. GENOMICS, 1998, 49 (03) : 452 - 457
  • [7] Mitochondrial translocation of cofilin is an early step in apoptosis induction
    Chua, BT
    Volbracht, C
    Tan, KO
    Li, R
    Yu, VC
    Li, P
    [J]. NATURE CELL BIOLOGY, 2003, 5 (12) : 1083 - 1089
  • [8] NUCLEOTIDE EXCHANGE BETWEEN CYTOSOLIC ATP AND F-ACTIN-BOUND ADP MAY BE A MAJOR ENERGY-UTILIZING PROCESS IN UNSTIMULATED PLATELETS
    DANIEL, JL
    MOLISH, IR
    ROBKIN, L
    HOLMSEN, H
    [J]. EUROPEAN JOURNAL OF BIOCHEMISTRY, 1986, 156 (03): : 677 - 684
  • [9] Generation of superoxide anion by mitochondria and impairment of their functions during anoxia and reoxygenation in vitro
    Du, G
    Mouithys-Mickalad, A
    Sluse, FE
    [J]. FREE RADICAL BIOLOGY AND MEDICINE, 1998, 25 (09) : 1066 - 1074
  • [10] Induction of replicative senescence biomarkers by sublethal oxidative stresses in normal human fibroblast
    Dumont, P
    Burton, M
    Chen, QM
    Gonos, ES
    Frippiat, C
    Mazarati, JB
    Eliaers, F
    Remacle, J
    Toussaint, O
    [J]. FREE RADICAL BIOLOGY AND MEDICINE, 2000, 28 (03) : 361 - 373
123456