Multicenter Study of Quantitative SPECT: Reproducibility of 99mT c Quantitation Using a Conjugated-Gradient Minimization Reconstruction Algorithm

被引：3

作者：

Okuda, Kyohei ^{[1
]}

Hasegawa, Daisuke ^{[2
]}

Kamiya, Takashi ^{[3
]}

Ichikawa, Hajime ^{[4
]}

Umeda, Takuro ^{[5
]}

Ohkubo, Takushi ^{[6
]}

Miwa, Kenta ^{[7
]}

机构：

[1] Tottori Univ Hosp, Dept Clin Radiol, 36-1 Nishi Cho, Yonago, Tottori 6838504, Japan

[2] Okayama Saiseikai Gen Hosp, Dept Radiol, Okayama, Japan

[3] Osaka Univ Hosp, Dept Med Technol, Div Radiol, Suita, Osaka, Japan

[4] Toyohashi Municipal Hosp, Dept Radiol, Toyohashi, Aichi, Japan

[5] Japan Fdn Canc Res, Dept Nucl Med, Canc Inst Hosp, Tokyo, Japan

[6] Toho Univ Omori, Cent Div Radiol, Med Ctr, Tokyo, Japan

[7] Int Univ Hlth & Welf, Sch Hlth Sci, Ohtawara, Japan

来源：

JOURNAL OF NUCLEAR MEDICINE TECHNOLOGY | 2021年 / 49卷 / 02期

关键词：

SPECT/CT; OSCGM; quantification; dose calibrator; Tc-99m-MDP; RESOLUTION RECOVERY; DOSE CALIBRATORS; PET; PERFORMANCE; ACCURACY; VOLUME;

D O I：

10.2967/jnmt.120.256131

中图分类号：

R8 [特种医学]; R445 [影像诊断学];

学科分类号：

1002 ; 100207 ; 1009 ;

摘要：

This multicenter study aimed to determine the reproducibility of quantitative SPECT images reconstructed using a commercially available method of ordered-subset conjugate-gradient minimization. Methods: A common cylindric phantom containing a 100 kBq/mL concentration of Tc-99m-pertechnetate solution in a volume of 7 L was scanned under standard imaging conditions at 6 institutions using the local clinical protocol of each. Interinstitutional variation among the quantitative SPECT images was evaluated using the coefficient of variation. Dose calibrator accuracy was also investigated by measuring the same lot of commercially available 99mTc vials at each institution. Results: The respective radioactivity concentrations under standard and clinical conditions ranged from 95.71 +/- 0.60 (mean +/- SD) to 108.35 +/- 0.36 kBq/mL and from 96.78 +/- 0.64 to 108.49 +/- 0.11 kBq/mL, respectively. Interinstitutional variation in radioactivity concentration was 4.20%. The bias in the radioactivity concentrations in SPECT images was associated with the accuracy of the dose calibrator at each institution. Conclusion: The reproducibility of the commercially available quantitative SPECT reconstruction method is high and comparable to that of PET, for comparatively large (similar to 7 L), homogeneous objects.

引用

页码：138 / 142

页数：5