Chlorambucil synergizes with purine analogs in inducing in vitro cytotoxicity in B-cell chronic lymphocytic leukemia

被引：0

作者：

Callea, I

Console, G

Sculli, G

Filangeri, M

Messina, G

Morabito, F ^{[1
]}

机构：

[1] Azienda Osped Bianchi Melacrino Morelli, Div Ematol, Dipartimento Ematooncol, Ctr Trapianti Midollo Osseo & Terapia Sovramassim, I-89100 Reggio Calabria, Italy

[2] Azienda Osped Bianchi Melacrino Morelli, Dipartimento Ematooncol, Ctr Microcitemie & Biol Mol, I-89100 Reggio Calabria, Italy

来源：

HAEMATOLOGICA | 1998年 / 83卷 / 08期

关键词：

CLL; MTT assay; fludarabine; chlorambucil; 2-chlorodeoxyadenosine; cytotoxicity; drug synergism;

D O I：

暂无

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Combinations of different drug concentrations of CLB+FAMP and CLB+2-CDA were synergistic in, respectively, 42.9% and 34.8%. At leukemic cell survival less than or equal to 50%, 16.4% and 23.4% of all combinations were synergistic in the 2-CDA and FAMP groups, respectively. A significantly higher mean value of antagonistic interactions was observed in the 2-CDA group (p=0.037).

引用

页码：756 / 757

页数：2

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