Chlorambucil synergizes with purine analogs in inducing in vitro cytotoxicity in B-cell chronic lymphocytic leukemia

被引：0
|
作者：
Callea, I
Console, G
Sculli, G
Filangeri, M
Messina, G
Morabito, F [1 ]
机构：
[1] Azienda Osped Bianchi Melacrino Morelli, Div Ematol, Dipartimento Ematooncol, Ctr Trapianti Midollo Osseo & Terapia Sovramassim, I-89100 Reggio Calabria, Italy
[2] Azienda Osped Bianchi Melacrino Morelli, Dipartimento Ematooncol, Ctr Microcitemie & Biol Mol, I-89100 Reggio Calabria, Italy
来源：
HAEMATOLOGICA | 1998年 / 83卷 / 08期
关键词：
CLL; MTT assay; fludarabine; chlorambucil; 2-chlorodeoxyadenosine; cytotoxicity; drug synergism;
D O I：
暂无
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
Combinations of different drug concentrations of CLB+FAMP and CLB+2-CDA were synergistic in, respectively, 42.9% and 34.8%. At leukemic cell survival less than or equal to 50%, 16.4% and 23.4% of all combinations were synergistic in the 2-CDA and FAMP groups, respectively. A significantly higher mean value of antagonistic interactions was observed in the 2-CDA group (p=0.037).
引用
收藏
页码：756 / 757
页数：2
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