Synthesis of linked berberine dimers and their remarkably enhanced DNA-binding affinities

被引：66

作者：

Chen, WH ^{[1
]}

Pang, JY

Qin, Y

Peng, Q

Cai, ZW

Jiang, ZH

机构：

[1] Sun Yat Sen Univ, Sch Chem & Chem Engn, Guangzhou 510275, Peoples R China

[2] Hong Kong Baptist Univ, Sch Chinese Med, Kowloon, Hong Kong, Peoples R China

[3] Hong Kong Baptist Univ, Dept Chem, Kowloon, Hong Kong, Peoples R China

来源：

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 2005年 / 15卷 / 10期

关键词：

D O I：

10.1016/j.bmcl.2004.10.098

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

This communication describes the facile synthesis of five novel berberine dimers and their strong affinities toward double-stranded DNA. These berberine dimers were synthesized in 37-84% yields from the reaction of berberrubine with dihaloalkanes of varying lengths, and fully characterized by HRMS and H-1 NMR. Compared with the monomeric parent berberine, these dimers showed greatly enhanced binding affinities up to approximately 100-fold, with two double helical oligodeoxynucleotides, d(AAGAATTCTT)(2) and d(TAAGAATTCTTA)(2), which was investigated by means of fluorescence spectrometry. (c) 2005 Elsevier Ltd. All rights reserved.

引用

页码：2689 / 2692

页数：4

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