Novel Alkaloids from Alstonia scholaris

被引：33

作者：

Cai, Xiang-Hai ^{[1
]}

Shang, Jian-Hua ^{[2
]}

Feng, Tao ^{[1
]}

Luo, Xiao-Dong ^{[1
]}

机构：

[1] Chinese Acad Sci, State Key Lab Phytochem & Plant Resources, W China Kunming Inst Bot, Kunming 650204, Yunana, Peoples R China

[2] Yunnan Inst Med Mat, Kunming 650111, Peoples R China

来源：

ZEITSCHRIFT FUR NATURFORSCHUNG SECTION B-A JOURNAL OF CHEMICAL SCIENCES | 2010年 / 65卷 / 09期

基金：

中国国家自然科学基金;

关键词：

Alstonia scholaris; Scholarisines I and II COX; 5; LOX; INDOLE ALKALOIDS; BIOSYNTHESIS;

D O I：

10.1515/znb-2010-0918

中图分类号：

O61 [无机化学];

学科分类号：

070301 ; 081704 ;

摘要：

The alkaloidal fraction of Alstonia scholaris leaves shows anti inflammatory and analgesic bioactivity in two A phytochemical study on this fraction led to the isolation of two novel alkaloids scholarisine I and (+/-)-scholarisine II Their structures were elucidated on the basis of spectroscopic methods and a possible biogenesis is proposed (+/-) Scholarisine II selectively inhibited the inducible COX-2 rather than COX-1 and also markedly inhibited 5-LOX comparable to positive controls

引用

页码：1164 / 1168

页数：5

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