Management of Patients with Sickle Cell Disease Using Transfusion Therapy Guidelines and Complications

被引：82

作者：

Chou, Stella T. ^{[1
]}

Fasano, Ross M. ^{[2
,3
,4
]}

机构：

[1] Univ Penn, Dept Pediat, Abramson Res Ctr, Childrens Hosp Philadelphia,Perelman Sch Med, 316D,3615 Civic Ctr Blvd, Philadelphia, PA 19104 USA

[2] Emory Univ, Transfus Tissue & Apheresis, Childrens Healthcare Atlanta, Sch Med, 7105B Woodruff Mem Bldg,101 Woodruff Circle, Atlanta, GA 30322 USA

[3] Emory Univ, Grady Hlth Syst Transfus Serv, Dept Clin Pathol, Sch Med, 7105B Woodruff Mem Bldg,101 Woodruff Circle, Atlanta, GA 30322 USA

[4] Emory Univ, Grady Hlth Syst Transfus Serv, Dept Pediat Hematol, Sch Med, 7105B Woodruff Mem Bldg,101 Woodruff Circle, Atlanta, GA 30322 USA

来源：

HEMATOLOGY-ONCOLOGY CLINICS OF NORTH AMERICA | 2016年 / 30卷 / 03期

关键词：

Sickle cell disease; Red blood cell transfusion; Alloimmunization; Iron overload; ACUTE CHEST SYNDROME; SILENT CEREBRAL INFARCTS; STROKE-PREVENTION TRIAL; PULMONARY-HYPERTENSION; BLOOD-TRANSFUSION; IRON OVERLOAD; I TREAT; PEDIATRIC-PATIENTS; ADULT PATIENTS; OVERT STROKE;

D O I：

10.1016/j.hoc.2016.01.011

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Red blood cell (RBC) transfusion therapy is a key component of comprehensive management of patients with sickle cell disease (SCD) and has increased over time as a means of primary and secondary stroke prevention. RBC transfusions also prove to be lifesaving for many acute sickle cell related complications. Although episodic and chronic transfusion therapy has significantly improved the morbidity and mortality of patients with SCD, transfusions are not without adverse effects. This review addresses RBC transfusion methods, evidence-based and/or expert panel based consensus on indications for chronic and episodic transfusion indications, and strategies to prevent and manage transfusion related complications.

引用

页码：591 / +

页数：19

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