Combination treatment of allergic rhinitis using ketotifen fumarate and budesonide administered as nasal sprays

被引：3

作者：

Wang, Shu-Zhen ^{[1
]}

Yao, Yuan ^{[1
]}

Zhang, Xiu-Ju ^{[1
]}

Duan, Xing ^{[1
]}

Guo, Liang-Rong ^{[1
]}

Jia, Yun ^{[1
]}

Wang, Dan ^{[1
]}

Tian, Yong-Sheng ^{[1
]}

机构：

[1] Aerosp Ctr Hosp, Dept Otolaryngol Head & Neck Surg, 15 Yuquan Rd, Beijing 100049, Peoples R China

来源：

INTERNATIONAL JOURNAL OF CLINICAL PHARMACOLOGY AND THERAPEUTICS | 2020年 / 58卷 / 04期

关键词：

ketotifen fumarate; budesonide; allergic rhinitis; ASTHMA;

D O I：

10.5414/CP203562

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

Objective: This study aims to evaluate the clinical efficacy of ketotifen fumarate and budesonide administered as nasal sprays to treat allergic rhinitis. Materials and methods: A total of 96 allergic rhinitis patients, who were admitted to our hospital in recent years, were selected as research subjectes. All patients were treated with ketotifen fumarate and budesonide administered as nasal sprays. Clinical efficacy was evaluated after treatment. Results: After treatment, the symptoms of nasal obstruction, nasal itching, sneezing, and runny nose significantly improved, and the score of these symptoms was significantly lower when compared to that before treatment (p < 0.05). After treatment, the eosinophils and IgE in peripheral blood of patients obviously reduced (p < 0.05). Conclusion: Combination treatment of allergic rhinitis using ketotifen fumarate and budesonide administered as nasal sprays has a good clinical effect in treating allergic rhinitis, which is of great significance to improve the clinical symptoms and immune function of patients. Ketotifen fumarate and budesonide have good therapeutic effects on allergic rhinitis. The combination of these two drugs can rapidly relieve allergic symptoms.

引用

页码：195 / 197

页数：3

共 10 条

[1] Allergic rhinitis and its impact on asthma (ARIA) 2008 update (in collaboration with the World Health Organization, GA2LEN and AllerGen) [J].

Bousquet, J. ;

Khaltaev, N. ;

Cruz, A. A. ;

Denburg, J. ;

Fokkens, W. J. ;

Togias, A. ;

Zuberbier, T. ;

Baena-Cagnani, C. E. ;

Canonica, G. W. ;

van Weel, C. ;

Agache, I. ;

Ait-Khaled, N. ;

Bachert, C. ;

Blaiss, M. S. ;

Bonini, S. ;

Boulet, L. -P. ;

Bousquet, P. -J. ;

Camargos, P. ;

Carlsen, K. -H. ;

Chen, Y. ;

Custovic, A. ;

Dahl, R. ;

Demoly, P. ;

Douagui, H. ;

Durham, S. R. ;

van Wijk, R. Gerth ;

Kalayci, O. ;

Kaliner, M. A. ;

Kim, Y. -Y. ;

Kowalski, M. L. ;

Kuna, P. ;

Le, L. T. T. ;

Lemiere, C. ;

Li, J. ;

Lockey, R. F. ;

Mavale-Manuel, S. ;

Meltzer, E. O. ;

Mohammad, Y. ;

Mullol, J. ;

Naclerio, R. ;

Hehir, R. E. O. ;

Ohta, K. ;

Ouedraogo, S. ;

Palkonen, S. ;

Papadopoulos, N. ;

Passalacqua, G. ;

Pawankar, R. ;

Popov, T. A. ;

Rabe, K. F. ;

Rosado-Pinto, J. .

ALLERGY, 2008, 63 :8-+

[2] Guidance to 2018 good practice: ARIA digitally-enabled, integrated, person-centred care for rhinitis and asthma [J].

Bousquet, J. ;

Bedbrook, A. ;

Czarlewski, W. ;

Onorato, G. L. ;

Arnavielhe, S. ;

Laune, D. ;

Mathieu-Dupas, E. ;

Fonseca, J. ;

Costa, E. ;

Lourenco, O. ;

Morais-Almeida, M. ;

Todo-Bom, A. ;

Illario, M. ;

Menditto, E. ;

Canonica, G. W. ;

Cecchi, L. ;

Monti, R. ;

Napoli, L. ;

Ventura, M. T. ;

De Feo, G. ;

Fokkens, W. J. ;

Chavannes, N. H. ;

Reitsma, S. ;

Cruz, A. A. ;

da Silva, J. ;

Serpa, F. S. ;

Larenas-Linnemann, D. ;

Perez, J. M. Fuentes ;

Huerta-Villalobos, Y. R. ;

Rivero-Yeverino, D. ;

Rodriguez-Zagal, E. ;

Valiulis, A. ;

Dubakiene, R. ;

Emuzyte, R. ;

Kvedariene, V. ;

Annesi-Maesano, I. ;

Blain, H. ;

Bonniaud, P. ;

Bosse, I. ;

Dauvilliers, Y. ;

Devillier, P. ;

Fontaine, J. F. ;

Pepin, J. L. ;

Pham-Thi, N. ;

Portejoie, F. ;

Picard, R. ;

Roche, N. ;

Rolland, C. ;

Schmidt-Grendelmeier, P. ;

Kuna, P. .

CLINICAL AND TRANSLATIONAL ALLERGY, 2019, 9

[3] Household dampness-related exposures in relation to childhood asthma and rhinitis in China: A multicentre observational study [J].

Cai, Jiao ;

Li, Baizhan ;

Yu, Wei ;

Wang, Han ;

Du, Chenqiu ;

Zhang, Yinping ;

Huang, Chen ;

Zhao, Zhuohui ;

Deng, Qihong ;

Yang, Xu ;

Zhang, Xin ;

Qian, Hua ;

Sun, Yuexia ;

Liu, Wei ;

Wang, Juan ;

Yang, Qin ;

Zeng, Fanbin ;

Norback, Dan ;

Sundell, Jan .

ENVIRONMENT INTERNATIONAL, 2019, 126 :735-746

[4] Comparison of the efficacy and mechanisms of intranasal budesonide, montelukast, and their combination in treatment of patients with seasonal allergic rhinitis [J].

Chen, Hui ;

Lou, Hongfei ;

Wang, Yang ;

Cao, Feifei ;

Zhang, Luo ;

Wang, Chengshuo .

INTERNATIONAL FORUM OF ALLERGY & RHINOLOGY, 2018, 8 (11) :1242-1252

[5]

[崔星 Cui Xing], 2017, [中国中医药信息杂志, Chinese Journal of Information on Traditional Chinese Medicine], V24, P18

[6]

Doulaptsi M, 2019, MED SCI BASEL, V7, pE38

[7] Japanese guidelines for allergic rhinitis 2017 [J].

Okubo, Kimihiro ;

Kurono, Yuichi ;

Ichimura, Keiichi ;

Enomoto, Tadao ;

Okamoto, Yoshitaka ;

Kawauchi, Hideyuki ;

Suzaki, Harumi ;

Fujieda, Shigeharu ;

Masuyama, Keisuke .

ALLERGOLOGY INTERNATIONAL, 2017, 66 (02) :205-219

[8]

Sharir M, 2018, ISSAC'18: PROCEEDINGS OF THE 2018 ACM INTERNATIONAL SYMPOSIUM ON SYMBOLIC AND ALGEBRAIC COMPUTATION, P1, DOI [10.1080/01430750.2018.1517687, 10.1145/3208976.3209028]

[9] Generic selection criteria for safety and patient benefit [V]: Comparing the pharmaceutical properties and patient usability of original and generic nasal spray containing ketotifen fumarate [J].

Wada, Yuko ;

Ami, Shyoko ;

Nozawa, Mitsuru ;

Goto, Miho ;

Shimokawa, Ken-ichi ;

Ishii, Fumiyoshi .

DRUG DISCOVERIES AND THERAPEUTICS, 2016, 10 (02) :88-92

[10]

Xu X, 2017, HAINAN YIXUEYUAN XUE, V23, P3032

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