Advanced Contrast-Enhanced MRI for Looking Beyond the Lumen to Predict Stroke Building a Risk Profile for Carotid Plaque

被引：58

作者：

Wasserman, Bruce A. ^{[1
]}

机构：

[1] Johns Hopkins Univ Hosp, Russell H Morgan Dept Radiol & Radiol Sci, Baltimore, MD 21287 USA

来源：

STROKE | 2010年 / 41卷 / 10期

关键词：

atherosclerosis; carotid artery; carotid plaque; carotid stenosis; imaging; magnetic resonance; MRI; risk factors; stroke risk; RICH NECROTIC CORE; IN-VIVO ACCURACY; INTRAPLAQUE HEMORRHAGE; HIGH-RESOLUTION; FIBROUS CAP; ANGIOGENESIS; ASSOCIATION; PROGRESSION; STENOSIS; RUPTURE;

D O I：

10.1161/STROKEAHA.110.596288

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

Carotid plaque MRI can identify components indicative of stroke risk, including the thin/ruptured fibrous cap and lipid core. Gadolinium contrast, typically administered for routine MR angiography acquisitions, can be used to improve plaque characterization, extending risk assessment beyond the plaque's hemodynamic impact on the lumen. Gadolinium preferentially enhances the cap, improves reliability of vessel wall measurements, and highlights neovessels, improving stroke risk stratification. Additionally, the precontrast series from the contrast-enhanced MR angiography can help identify intraplaque hemorrhage, another important risk marker. Prospective validation of these features is needed to develop a carotid plaque risk profile for clinical implementation. (Stroke. 2010;41[suppl 1]:S12-S16.)

引用

页码：S12 / S16

页数：5

共 28 条

[1] Detection of intraplaque hemorrhage by magnetic resonance imaging in symptomatic patients with mild to moderate carotid stenosis predicts recurrent neurological events [J].

Altaf, Nishath ;

Daniels, Lucy ;

Morgan, Paul S. ;

Auer, Dorothee ;

MacSweeney, Shane T. ;

Moody, Alan R. ;

Gladman, John R. .

JOURNAL OF VASCULAR SURGERY, 2008, 47 (02) :337-342

[2] In vivo quantitative measurement of intact fibrous cap and lipid-rich necrotic core size in atherosclerotic carotid plaque - Comparison of high-resolution, contrast-enhanced magnetic resonance imaging and histology [J].

Cai, JM ;

Hatsukami, TS ;

Ferguson, MS ;

Kerwin, WS ;

Saam, T ;

Chu, BC ;

Takaya, N ;

Polissar, NL ;

Yuan, C .

CIRCULATION, 2005, 112 (22) :3437-3444

[3] Hemorrhage in the atherosclerotic carotid plaque: A high-resolution MRI study [J].

Chu, BC ;

Kampschulte, A ;

Ferguson, MS ;

Kerwin, WS ;

Yarnykh, VL ;

O'Brien, KD ;

Polissar, NL ;

Hatsukami, TS ;

Yuan, C .

STROKE, 2004, 35 (05) :1079-1084

[4] CORONARY PLAQUE DISRUPTION [J].

FALK, E ;

SHAH, PK ;

FUSTER, V .

CIRCULATION, 1995, 92 (03) :657-671

[5] The causes and risk of stroke in patients with asymptomatic internal-carotid-artery stenosis [J].

Inzitari, D ;

Eliasziw, M ;

Gates, P ;

Sharpe, BL ;

Chan, RKT ;

Meldrum, HE ;

Barnett, HJM .

NEW ENGLAND JOURNAL OF MEDICINE, 2000, 342 (23) :1693-1700

[6] MR imaging of adventitial vasa vasorum in carotid atherosclerosis [J].

Kerwin, W. S. ;

Oikawa, M. ;

Yuan, C. ;

Jarvik, G. P. ;

Hatsukami, T. S. .

MAGNETIC RESONANCE IN MEDICINE, 2008, 59 (03) :507-514

[7] Intraplaque hemorrhage and progression of coronary atheroma [J].

Kolodgie, FD ;

Gold, HK ;

Burke, AP ;

Fowler, DR ;

Kruth, HS ;

Weber, DK ;

Farb, A ;

Guerrero, LJ ;

Hayase, M ;

Kutys, R ;

Narula, J ;

Finn, AV ;

Virmani, R .

NEW ENGLAND JOURNAL OF MEDICINE, 2003, 349 (24) :2316-2325

[8] Reproducibility of Fibrous Cap Status Assessment of Carotid Artery Plaques by Contrast-Enhanced MRI [J].

Kwee, Robert M. ;

van Engelshoven, Jos M. A. ;

Mess, Werner H. ;

ter Berg, Johannes W. M. ;

Schreuder, Floris H. B. M. ;

Franke, Cees L. ;

Korten, Arthur G. G. C. ;

Meems, Be J. ;

van Oostenbrugge, Robert J. ;

Wildberger, Joachim E. ;

Kooi, Marianne E. .

STROKE, 2009, 40 (09) :3017-3021

[9] Angiogenesis and the atherosclerotic carotid plaque: An association between symptomatology and plaque morphology [J].

McCarthy, MJ ;

Loftus, IM ;

Thompson, MM ;

Jones, L ;

London, NJM ;

Bell, PRF ;

Naylor, AR ;

Brindle, NPJ .

JOURNAL OF VASCULAR SURGERY, 1999, 30 (02) :261-268

[10] In vivo accuracy of multisequence MR imaging for identifying unstable fibrous caps in advanced human carotid plaques [J].

Mitsumori, LM ;

Hatsukami, TS ;

Ferguson, MS ;

Kerwin, WS ;

Cai, JM ;

Yuan, C .

JOURNAL OF MAGNETIC RESONANCE IMAGING, 2003, 17 (04) :410-420

← 1 2 3 →