High glucose, no cry

被引：2

作者：

Bass, Joseph ^{[1
,2
]}

机构：

[1] Northwestern Univ, Dept Med, Feinberg Sch Med, Chicago, IL 60611 USA

[2] Northwestern Univ, Dept Neurobiol & Physiol, Weinberg Coll Arts & Sci, Ctr Sleep & Circadian Biol, Chicago, IL 60611 USA

来源：

NATURE MEDICINE | 2010年 / 16卷 / 10期

关键词：

HOMEOSTASIS;

D O I：

10.1038/nm1010-1074

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Just as a Bob Marley tune can elicit a visceral pull, a rhythmic awakening can shake up metabolism, with a new study in mice showing that cryptochrome (CRY) in the liver controls glucose levels during fasting and improves insulin sensitivity—introducing a new possible therapy for type II diabetes (pages 1152–1156).

引用

页码：1074 / 1076

页数：4

共 14 条

[1] Network Features of the Mammalian Circadian Clock [J].

Baggs, Julie E. ;

Price, Tom S. ;

DiTacchio, Luciano ;

Panda, Satchidananda ;

FitzGerald, Garret A. ;

Hogenesch, John B. .

PLOS BIOLOGY, 2009, 7 (03) :563-575

[2] A serum shock induces circadian gene expression in mammalian tissue culture cells [J].

Balsalobre, A ;

Damiola, F ;

Schibler, U .

CELL, 1998, 93 (06) :929-937

[3] New genetic loci implicated in fasting glucose homeostasis and their impact on type 2 diabetes risk [J].

Dupuis, Josee ;

Langenberg, Claudia ;

Prokopenko, Inga ;

Saxena, Richa ;

Soranzo, Nicole ;

Jackson, Anne U. ;

Wheeler, Eleanor ;

Glazer, Nicole L. ;

Bouatia-Naji, Nabila ;

Gloyn, Anna L. ;

Lindgren, Cecilia M. ;

Magi, Reedik ;

Morris, Andrew P. ;

Randall, Joshua ;

Johnson, Toby ;

Elliott, Paul ;

Rybin, Denis ;

Thorleifsson, Gudmar ;

Steinthorsdottir, Valgerdur ;

Henneman, Peter ;

Grallert, Harald ;

Dehghan, Abbas ;

Hottenga, Jouke Jan ;

Franklin, Christopher S. ;

Navarro, Pau ;

Song, Kijoung ;

Goel, Anuj ;

Perry, John R. B. ;

Egan, Josephine M. ;

Lajunen, Taina ;

Grarup, Niels ;

Sparso, Thomas ;

Doney, Alex ;

Voight, Benjamin F. ;

Stringham, Heather M. ;

Li, Man ;

Kanoni, Stavroula ;

Shrader, Peter ;

Cavalcanti-Proenca, Christine ;

Kumari, Meena ;

Qi, Lu ;

Timpson, Nicholas J. ;

Gieger, Christian ;

Zabena, Carina ;

Rocheleau, Ghislain ;

Ingelsson, Erik ;

An, Ping ;

O'Connell, Jeffrey ;

Luan, Jian'an ;

Elliott, Amanda .

NATURE GENETICS, 2010, 42 (02) :105-U32

[4] The meter of metabolism [J].

Green, Carla B. ;

Takahashi, Joseph S. ;

Bass, Joseph .

CELL, 2008, 134 (05) :728-742

[5] Physiological significance of a peripheral tissue circadian clock [J].

Lamia, Katja A. ;

Storch, Kai-Florian ;

Weitz, Charles J. .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2008, 105 (39) :15172-15177

[6] Disruption of the clock components CLOCK and BMAL1 leads to hypoinsulinaemia and diabetes [J].

Marcheva, Biliana ;

Ramsey, Kathryn Moynihan ;

Buhr, Ethan D. ;

Kobayashi, Yumiko ;

Su, Hong ;

Ko, Caroline H. ;

Ivanova, Ganka ;

Omura, Chiaki ;

Mo, Shelley ;

Vitaterna, Martha H. ;

Lopez, James P. ;

Philipson, Louis H. ;

Bradfield, Christopher A. ;

Crosby, Seth D. ;

JeBailey, Lellean ;

Wang, Xiaozhong ;

Takahashi, Joseph S. ;

Bass, Joseph .

NATURE, 2010, 466 (7306) :627-631

[7] cAMP-dependent signaling as a core component of the mammalian circadian pacemaker [J].

O'Neill, John S. ;

Maywood, Elizabeth S. ;

Chesham, Johanna E. ;

Takahashi, Joseph S. ;

Hastings, Michael H. .

SCIENCE, 2008, 320 (5878) :949-953

[8] Nutrient control of glucose homeostasis through a complex of PGC-1α and SIRT1 [J].

Rodgers, JT ;

Lerin, C ;

Haas, W ;

Gygi, SP ;

Spiegelman, BM ;

Puigserver, P .

NATURE, 2005, 434 (7029) :113-118

[9] BMAL1 and CLOCK, two essential components of the circadian clock, are involved in glucose homeostasis [J].

Rudic, RD ;

McNamara, P ;

Curtis, AM ;

Boston, RC ;

Panda, S ;

Hogenesch, JB ;

FitzGerald, GA .

PLOS BIOLOGY, 2004, 2 (11) :1893-1899

[10] Opinion - Metabolic cycles as an underlying basis of biological oscillations [J].

Tu, Benjamin P. ;

McKnight, Steven L. .

NATURE REVIEWS MOLECULAR CELL BIOLOGY, 2006, 7 (09) :696-701

← 1 2 →