Optical palpation in vivo: imaging human skin lesions using mechanical contrast

被引:26
作者
Es'haghian, Shaghayegh
Kennedy, Kelsey M.
Gong, Peijun
Sampson, David D.
McLaughlin, Robert A.
Kennedy, Brendan F.
机构
[1] University of Western Australia, School of Electrical, Electronic and Computer Engineering, Optical+Biomedical Engineering Laboratory, 35 Stirling Highway, Crawley, 6009, WA
[2] University of Western Australia, Centre for Microscopy, Characterisation and Analysis, 35 Stirling Highway, Crawley, 6009, WA
基金
英国医学研究理事会; 澳大利亚研究理事会;
关键词
optical coherence tomography; optical coherence elastography; tactile imaging; optical palpation; biomechanics; skin; scar; skin lesion; COHERENCE TOMOGRAPHY; INDENTATION TEST; BURN SCAR; ELASTOGRAPHY; INVIVO; AGE; THICKNESS; ULTRASOUND; THRESHOLD; STIFFNESS;
D O I
10.1117/1.JBO.20.1.016013
中图分类号
Q5 [生物化学];
学科分类号
071010 ; 081704 ;
摘要
We demonstrate the first application of the recently proposed method of optical palpation to in vivo imaging of human skin. Optical palpation is a tactile imaging technique that probes the spatial variation of a sample's mechanical properties by producing an en face map of stress measured at the sample surface. This map is determined from the thickness of a translucent, compliant stress sensor placed between a loading element and the sample and is measured using optical coherence tomography. We assess the performance of optical palpation using a handheld imaging probe on skin-mimicking phantoms, and demonstrate its use on human skin lesions. Our results demonstrate the capacity of optical palpation to delineate the boundaries of lesions and to map the mechanical contrast between lesions and the surrounding normal skin. (C) 2015 Society of Photo-Optical Instrumentation Engineers (SPIE)
引用
收藏
页数:11
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