Spectroscopic Investigation on the Toxic Interaction of Melamine with Herring Sperm DNA

被引：13
作者：
Sun, Yajing [1 ]
Liu, Rutao [1 ]
Chi, Zhenxing [1 ]
Qin, Pengfei [1 ]
Fang, Xiaoyan [1 ]
Mou, Yue [1 ]
机构：
[1] Shandong Univ, Sch Environm Sci & Engn, Jinan 250100, Peoples R China
来源：
JOURNAL OF BIOCHEMICAL AND MOLECULAR TOXICOLOGY | 2010年 / 24卷 / 05期
关键词：
DNA; Melamine; Toxic Interaction; BOVINE SERUM-ALBUMIN; CALF THYMUS DNA; FORMALDEHYDE RESINS; FLUORESCENCE PROBE; METHYLENE-BLUE; MECHANISM; COMPLEXES; BINDING; CANCER; ACID;
D O I：
10.1002/jbt.20341
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
The toxic interaction of melamine with herring sperm DNA (hs-DNA) was investigated by using fluorescence and UV-vis absorption spectra techniques. The experimental results showed that the toxic interaction between melamine and hs-DNA occurred. Fluorescence quenching experiments indicated the existence of electrostatic binding between melamine and hs-DNA. The binding constants K-A and the binding site numbers were calculated by means of the Stern Volmer equation and were 9.8 x 10(4) L mol(-1) and 1.3, respectively. Both the results of fluorescence spectra and UV vis absorption spectra verified that there are electrostatic binding between melamine and hs-DNA. The possibility in the presence of a classical intercalation binding mode could be ruled out by using DNA unwinding experiments. (C) 2010 Wiley Periodicals, Inc. J Biochem Mol Toxicol 24:323-329, 2010; View this article online at wileyonlinelibrary.com. DOI 10:1002/jbt.20341
引用
收藏
页码：323 / 329
页数：7
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