RETRACTED: The preoperative platelet-lymphocyte ratio versus neutrophil-lymphocyte ratio: which is better as a prognostic factor in oral squamous cell carcinoma? (Retracted article. See vol. 14, 2022)

被引：58
作者：
Chen, Shan [1 ]
Guo, Junbing [1 ]
Feng, Chongjin [1 ]
Ke, Zunfu [2 ]
Chen, Leihui [1 ]
Pan, Yunping [1 ]
机构：
[1] Sun Yat Sen Univ, Affiliated Hosp 1, Dept Oral & Maxillofacial Surg, 58 Zhongshan Rd 2, Guangzhou 510080, Guangdong, Peoples R China
[2] Sun Yat Sen Univ, Dept Pathol, Affiliated Hosp 1, Guangzhou 510080, Guangdong, Peoples R China
来源：
THERAPEUTIC ADVANCES IN MEDICAL ONCOLOGY | 2016年 / 8卷 / 03期
基金：
中国国家自然科学基金;
关键词：
neutrophil to lymphocyte ratio; oral squamous cell carcinoma; platelet to lymphocyte ratio; prognostic factor; NEUTROPHIL/LYMPHOCYTE RATIO; HEPATOCELLULAR-CARCINOMA; ELEVATED NEUTROPHIL; TUMOR-CELLS; SURVIVAL; CANCER; COUNT; CHEMOTHERAPY; RESECTION; MARKER;
D O I：
10.1177/1758834016638019
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
Objective: Recent studies have shown that the presence of systemic inflammation and platelet status correlate with poor survival in various cancers. The aim of this study was to evaluate the prognostic value of the preoperative platelet-lymphocyte ratio (PLR) and the neutrophil-lymphocyte ratio (NLR) in patients with oral squamous cell carcinoma (OSCC) undergoing surgery. Methods: In this study, 306 patients with OSCC who had surgery were enrolled. The optimal cutoff value of PLR and NLR was determined by receiver operating characteristic (ROC) curve analysis. The prognostic significance of both markers was determined by uni- and multivariate analysis. Results: The results showed that high NLR and PLR were classified using a cutoff value of 2.7 and 135, respectively, based on ROC curve analysis. Only PLR was associated with decreased disease-free survival [hazard ratio (HR) = 2.237; 95% confidence interval (CI): 1.401-3.571; p = 0.001] and overall survival [HR = 2.022; 95% CI: 1.266-3.228; p = 0.003] by both uni- and multivariate analysis. Conclusion: The preoperative PLR is superior to NLR as an independent indicator in predicting disease-free survival and overall survival in patients who undergo oral cancer resection for OSCC.
引用
收藏
页码：160 / 167
页数：8
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