Fluorescent-labeled DNA probes applied to novel biological aspects of B-cell chronic lymphocytic leukemia

被引：28
作者：
Fink, SR
Paternoster, SE
Smoley, SA
Flynn, HC
Geyer, SM
Shanafelt, TD
Lee, YK
Jelinek, DE
Kay, NE
Dewald, GW
机构：
[1] Mayo Clin & Mayo Fdn, Div Lab Genet, Rochester, MN 55905 USA
[2] Mayo Clin & Mayo Fdn, Div Hematol, Rochester, MN 55905 USA
[3] Mayo Clin & Mayo Fdn, Canc Ctr Stat, Rochester, MN 55905 USA
[4] Mayo Clin & Mayo Fdn, Dept Immunol, Rochester, MN 55905 USA
来源：
LEUKEMIA RESEARCH | 2005年 / 29卷 / 03期
关键词：
TCL1; IGHv; CLL; FISH; angiogenesis;
D O I：
10.1016/j.leukres.2004.07.012
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
Fluorescent-labeled DNA probes were used to study 52 chronic lymphocytic leukemia (B-CLL) patients for (1) disease progression, (2) angiogenesis genes, (3) T-cell leukemia 1 gene (TCL1), (4) immunoglobulin heavy chain variable region (IGHv) and (5) chromosome 6q. Compared to stable disease, more patients with progressive disease had greater than or equal to2 anomalies and a high percentage of neoplastic nuclei. Anomalies of genes for basic fibroblast growth factor, interleukin 4, vascular endothelial growth factor or TCL1 were not detected. Deletions in IGHv occurred in 25% of patients and correlated with IGHv gene expression. Probes for 6q23 detected more deletions in 6q than probes for 6q21. (C) 2004 Elsevier Ltd. All rights reserved.
引用
收藏
页码：253 / 262
页数：10
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