Stem cell-biomaterial interactions for regenerative medicine

被引：148

作者：

Martino, Sabata ^{[1
]}

D'Angelo, Francesco ^{[1
]}

Armentano, Ilaria ^{[2
]}

Maria Kenny, Jose ^{[2
,3
]}

Orlacchio, Aldo ^{[1
]}

机构：

[1] Univ Perugia, Dept Expt Med & Biochem Sci, Sect Biochem & Mol Biol, I-06100 Perugia, Italy

[2] Univ Perugia, NIPLAB, UdR INSTM, Mat Engn Ctr, Terni, Italy

[3] CSIC, Inst Polymer Sci & Technol, Madrid, Spain

来源：

BIOTECHNOLOGY ADVANCES | 2012年 / 30卷 / 01期

关键词：

Embryonic stem cells; Induced pluripotent stem cells; Adult stem cells; Biomaterials; Nanotopography; Bone tissue engineering; Neural tissue engineering; Skeletal and cardiac muscle tissue engineering; OSTEOBLAST-LIKE CELLS; HUMAN BONE-MARROW; SELF-RENEWAL; MECHANICAL-PROPERTIES; EXTRACELLULAR-MATRIX; MICRORNA EXPRESSION; NERVE REGENERATION; EPIGENETIC MODIFICATIONS; INDUCED PLURIPOTENT; HISTONE CHAPERONES;

D O I：

10.1016/j.biotechadv.2011.06.015

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 ; 0836 ; 090102 ; 100705 ;

摘要：

The synergism of stem cell biology and biomaterial technology promises to have a profound impact on stem-cell-based clinical applications for tissue regeneration. Biomaterials development is rapidly advancing to display properties that, in a precise and physiological fashion, could drive stem-cell fate both in vitro and in vivo. Thus, the design of novel materials is trying to recapitulate the molecular events involved in the production, clearance and interaction of molecules within tissue in pathologic conditions and regeneration of tissue/organs. In this review we will report on the challenges behind translating stem cell biology and biomaterial innovations into novel clinical therapeutic applications for tissue and organ replacements (graphical abstract). (C) 2011 Elsevier Inc. All rights reserved.

引用

页码：338 / 351

页数：14

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