Cellular oncogenesis involves a complex interplay between the several synchronized, interdependent pathways that collectively determine the pathogenesis and pathophysiology of cancer. Limited therapeutic success with the existing anticancer drugs drew huge interest in the design and development of new pharmacophores with improved clinical efficacy, however despite huge investments in anticancer RD; the average number of Food and Drug Administration-approved anticancer drugs declined since the 1990s. The contemporary anticancer medications possess high attrition rates, bear substantial costs, and experience low efficacy owing to the drug resistance expressed by the aggressive tumors. Mainly, the translation of novel candidate anticancer drugs into clinical practice, their commercialization, and transformation from the bench to bedside require a long timeframe of 10-15 years and capital worth millions of dollars. The repurposing strategy substantially accelerated the anticancer drug development regime as the approved drugs with tested safety and efficacy ensure a minimal risk of failure, and nominal R&D expenses as anticipated for the newly identified candidate drugs yet to enter the clinical trials. In addition, the repurposed drugs ensure a rapid clinical translation due to a validated clinical profile and their ability to target the identified hallmarks and hitherto unknown vulnerabilities of cancer. The flagship project "Repurposing Drugs in Oncology" (ReDO) identified 268 "hard repurposing" noncancer medications as candidate drugs with a promising anticancer profile (). However, the generic profile of 84% of repurposed drugs in ReDO data set discourages the commercial sponsors from funding the repurposing trials, especially the Phase III efficacy trials that require significant capital.
机构:
Univ Nacl Autonoma Mexico, Fac Quim, Dept Farm, Mexico City, DF, Mexico
Univ Nacl Autonoma Mexico, Fac Quim, Dept Fis Quim, Mexico City, DF, MexicoUniv Nacl Autonoma Mexico, Fac Quim, Dept Farm, Mexico City, DF, Mexico
Aguayo-Ortiz, Rodrigo
Cano-Gonzalez, Lucia
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Univ Nacl Autonoma Mexico, Fac Quim, Dept Farm, Mexico City, DF, MexicoUniv Nacl Autonoma Mexico, Fac Quim, Dept Farm, Mexico City, DF, Mexico
Cano-Gonzalez, Lucia
Castillo, Rafael
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Univ Nacl Autonoma Mexico, Fac Quim, Dept Farm, Mexico City, DF, MexicoUniv Nacl Autonoma Mexico, Fac Quim, Dept Farm, Mexico City, DF, Mexico
Castillo, Rafael
Hernandez-Campos, Alicia
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Univ Nacl Autonoma Mexico, Fac Quim, Dept Farm, Mexico City, DF, MexicoUniv Nacl Autonoma Mexico, Fac Quim, Dept Farm, Mexico City, DF, Mexico
Hernandez-Campos, Alicia
Dominguez, Laura
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Univ Nacl Autonoma Mexico, Fac Quim, Dept Fis Quim, Mexico City, DF, MexicoUniv Nacl Autonoma Mexico, Fac Quim, Dept Farm, Mexico City, DF, Mexico
机构:
Harvard Med Sch, Beth Israel Deaconess Med Ctr, Ctr Drug Discovery & Translat Res, Boston, MA 02215 USAHarvard Med Sch, Beth Israel Deaconess Med Ctr, Ctr Drug Discovery & Translat Res, Boston, MA 02215 USA
Cheong, Jae Eun
Zaffagni, Michela
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Harvard Med Sch, Boston Childrens Hosp, Vasc Biol Program, Boston, MA 02215 USAHarvard Med Sch, Beth Israel Deaconess Med Ctr, Ctr Drug Discovery & Translat Res, Boston, MA 02215 USA
Zaffagni, Michela
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Chung, Ivy
Xu, Yingjie
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Harvard Med Sch, Boston Childrens Hosp, Vasc Biol Program, Boston, MA 02215 USAHarvard Med Sch, Beth Israel Deaconess Med Ctr, Ctr Drug Discovery & Translat Res, Boston, MA 02215 USA
Xu, Yingjie
Wang, Yiqiang
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Harvard Med Sch, Beth Israel Deaconess Med Ctr, Ctr Drug Discovery & Translat Res, Boston, MA 02215 USAHarvard Med Sch, Beth Israel Deaconess Med Ctr, Ctr Drug Discovery & Translat Res, Boston, MA 02215 USA
Wang, Yiqiang
Jernigan, Finith E.
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Harvard Med Sch, Beth Israel Deaconess Med Ctr, Ctr Drug Discovery & Translat Res, Boston, MA 02215 USAHarvard Med Sch, Beth Israel Deaconess Med Ctr, Ctr Drug Discovery & Translat Res, Boston, MA 02215 USA
Jernigan, Finith E.
Zetter, Bruce R.
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Harvard Med Sch, Boston Childrens Hosp, Vasc Biol Program, Boston, MA 02215 USAHarvard Med Sch, Beth Israel Deaconess Med Ctr, Ctr Drug Discovery & Translat Res, Boston, MA 02215 USA
Zetter, Bruce R.
Sun, Lijun
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Harvard Med Sch, Beth Israel Deaconess Med Ctr, Ctr Drug Discovery & Translat Res, Boston, MA 02215 USAHarvard Med Sch, Beth Israel Deaconess Med Ctr, Ctr Drug Discovery & Translat Res, Boston, MA 02215 USA
机构:
Ist Super Sanita, Ctr Nazl Controllo & Valutaz Farm, I-00161 Rome, ItalyG dAnnunzio Univ Chieti Pescara, Dept Pharm, I-66100 Chieti, Italy
Cirilli, Roberto
Casulli, Adriano
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Ist Super Sanita, WHO Collaborating Ctr Epidemiol Detect & Control, I-00161 Rome, Italy
Ist Super Sanita, European Union Reference Lab Parasites, I-00161 Rome, ItalyG dAnnunzio Univ Chieti Pescara, Dept Pharm, I-66100 Chieti, Italy
机构:
Natl Inst Pharmaceut Educ & Res NIPER, Dept Med Chem, Sas Nagar 160062, Punjab, IndiaNatl Inst Pharmaceut Educ & Res NIPER, Dept Med Chem, Sas Nagar 160062, Punjab, India
Kasetti, Yoganjaneyulu
Bharatam, Prasad V.
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Natl Inst Pharmaceut Educ & Res NIPER, Dept Med Chem, Sas Nagar 160062, Punjab, IndiaNatl Inst Pharmaceut Educ & Res NIPER, Dept Med Chem, Sas Nagar 160062, Punjab, India
机构:
Natl Res Ctr, Dept Chem Nat & Microbial Prod, Div Pharmaceut & Drug Ind, Cairo 12622, EgyptNatl Res Ctr, Dept Chem Nat & Microbial Prod, Div Pharmaceut & Drug Ind, Cairo 12622, Egypt
Khattab, Muhammad
Al-Karmalawy, Ahmed A.
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机构:
Horus Univ Egypt, Fac Pharm, Dept Pharmaceut Med Chem, New Damietta 34518, EgyptNatl Res Ctr, Dept Chem Nat & Microbial Prod, Div Pharmaceut & Drug Ind, Cairo 12622, Egypt
机构:
Chungnam Natl Univ, Coll Vet Med, Dept Vet Internal Med, Daejeon, South KoreaChungnam Natl Univ, Coll Vet Med, Dept Vet Internal Med, Daejeon, South Korea
Perera, Shashini Kanchanamala
Choi, Seo-In
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Chungnam Natl Univ, Coll Vet Med, Dept Vet Internal Med, Daejeon, South KoreaChungnam Natl Univ, Coll Vet Med, Dept Vet Internal Med, Daejeon, South Korea
Choi, Seo-In
Rebhun, Robert B.
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Univ Calif Davis, Sch Vet Med, Ctr Compan Anim Hlth, Dept Surg & Radiol Sci, Davis, CA USAChungnam Natl Univ, Coll Vet Med, Dept Vet Internal Med, Daejeon, South Korea
Rebhun, Robert B.
Seo, Kyoung-won
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Seoul Natl Univ, Coll Vet Med, Dept Vet Internal Med, Seoul, South KoreaChungnam Natl Univ, Coll Vet Med, Dept Vet Internal Med, Daejeon, South Korea
机构:
Univ Nacl Autonoma Mexico, Fac Quim, Dept Farm, Mexico City, DF, Mexico
Univ Nacl Autonoma Mexico, Fac Quim, Dept Fis Quim, Mexico City, DF, MexicoUniv Nacl Autonoma Mexico, Fac Quim, Dept Farm, Mexico City, DF, Mexico
Aguayo-Ortiz, Rodrigo
Cano-Gonzalez, Lucia
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h-index: 0
机构:
Univ Nacl Autonoma Mexico, Fac Quim, Dept Farm, Mexico City, DF, MexicoUniv Nacl Autonoma Mexico, Fac Quim, Dept Farm, Mexico City, DF, Mexico
Cano-Gonzalez, Lucia
Castillo, Rafael
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h-index: 0
机构:
Univ Nacl Autonoma Mexico, Fac Quim, Dept Farm, Mexico City, DF, MexicoUniv Nacl Autonoma Mexico, Fac Quim, Dept Farm, Mexico City, DF, Mexico
Castillo, Rafael
Hernandez-Campos, Alicia
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h-index: 0
机构:
Univ Nacl Autonoma Mexico, Fac Quim, Dept Farm, Mexico City, DF, MexicoUniv Nacl Autonoma Mexico, Fac Quim, Dept Farm, Mexico City, DF, Mexico
Hernandez-Campos, Alicia
Dominguez, Laura
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Univ Nacl Autonoma Mexico, Fac Quim, Dept Fis Quim, Mexico City, DF, MexicoUniv Nacl Autonoma Mexico, Fac Quim, Dept Farm, Mexico City, DF, Mexico
机构:
Harvard Med Sch, Beth Israel Deaconess Med Ctr, Ctr Drug Discovery & Translat Res, Boston, MA 02215 USAHarvard Med Sch, Beth Israel Deaconess Med Ctr, Ctr Drug Discovery & Translat Res, Boston, MA 02215 USA
Cheong, Jae Eun
Zaffagni, Michela
论文数: 0引用数: 0
h-index: 0
机构:
Harvard Med Sch, Boston Childrens Hosp, Vasc Biol Program, Boston, MA 02215 USAHarvard Med Sch, Beth Israel Deaconess Med Ctr, Ctr Drug Discovery & Translat Res, Boston, MA 02215 USA
Zaffagni, Michela
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Chung, Ivy
Xu, Yingjie
论文数: 0引用数: 0
h-index: 0
机构:
Harvard Med Sch, Boston Childrens Hosp, Vasc Biol Program, Boston, MA 02215 USAHarvard Med Sch, Beth Israel Deaconess Med Ctr, Ctr Drug Discovery & Translat Res, Boston, MA 02215 USA
Xu, Yingjie
Wang, Yiqiang
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h-index: 0
机构:
Harvard Med Sch, Beth Israel Deaconess Med Ctr, Ctr Drug Discovery & Translat Res, Boston, MA 02215 USAHarvard Med Sch, Beth Israel Deaconess Med Ctr, Ctr Drug Discovery & Translat Res, Boston, MA 02215 USA
Wang, Yiqiang
Jernigan, Finith E.
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h-index: 0
机构:
Harvard Med Sch, Beth Israel Deaconess Med Ctr, Ctr Drug Discovery & Translat Res, Boston, MA 02215 USAHarvard Med Sch, Beth Israel Deaconess Med Ctr, Ctr Drug Discovery & Translat Res, Boston, MA 02215 USA
Jernigan, Finith E.
Zetter, Bruce R.
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h-index: 0
机构:
Harvard Med Sch, Boston Childrens Hosp, Vasc Biol Program, Boston, MA 02215 USAHarvard Med Sch, Beth Israel Deaconess Med Ctr, Ctr Drug Discovery & Translat Res, Boston, MA 02215 USA
Zetter, Bruce R.
Sun, Lijun
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h-index: 0
机构:
Harvard Med Sch, Beth Israel Deaconess Med Ctr, Ctr Drug Discovery & Translat Res, Boston, MA 02215 USAHarvard Med Sch, Beth Israel Deaconess Med Ctr, Ctr Drug Discovery & Translat Res, Boston, MA 02215 USA
机构:
Ist Super Sanita, Ctr Nazl Controllo & Valutaz Farm, I-00161 Rome, ItalyG dAnnunzio Univ Chieti Pescara, Dept Pharm, I-66100 Chieti, Italy
Cirilli, Roberto
Casulli, Adriano
论文数: 0引用数: 0
h-index: 0
机构:
Ist Super Sanita, WHO Collaborating Ctr Epidemiol Detect & Control, I-00161 Rome, Italy
Ist Super Sanita, European Union Reference Lab Parasites, I-00161 Rome, ItalyG dAnnunzio Univ Chieti Pescara, Dept Pharm, I-66100 Chieti, Italy
机构:
Natl Inst Pharmaceut Educ & Res NIPER, Dept Med Chem, Sas Nagar 160062, Punjab, IndiaNatl Inst Pharmaceut Educ & Res NIPER, Dept Med Chem, Sas Nagar 160062, Punjab, India
Kasetti, Yoganjaneyulu
Bharatam, Prasad V.
论文数: 0引用数: 0
h-index: 0
机构:
Natl Inst Pharmaceut Educ & Res NIPER, Dept Med Chem, Sas Nagar 160062, Punjab, IndiaNatl Inst Pharmaceut Educ & Res NIPER, Dept Med Chem, Sas Nagar 160062, Punjab, India
机构:
Natl Res Ctr, Dept Chem Nat & Microbial Prod, Div Pharmaceut & Drug Ind, Cairo 12622, EgyptNatl Res Ctr, Dept Chem Nat & Microbial Prod, Div Pharmaceut & Drug Ind, Cairo 12622, Egypt
Khattab, Muhammad
Al-Karmalawy, Ahmed A.
论文数: 0引用数: 0
h-index: 0
机构:
Horus Univ Egypt, Fac Pharm, Dept Pharmaceut Med Chem, New Damietta 34518, EgyptNatl Res Ctr, Dept Chem Nat & Microbial Prod, Div Pharmaceut & Drug Ind, Cairo 12622, Egypt
机构:
Chungnam Natl Univ, Coll Vet Med, Dept Vet Internal Med, Daejeon, South KoreaChungnam Natl Univ, Coll Vet Med, Dept Vet Internal Med, Daejeon, South Korea
Perera, Shashini Kanchanamala
Choi, Seo-In
论文数: 0引用数: 0
h-index: 0
机构:
Chungnam Natl Univ, Coll Vet Med, Dept Vet Internal Med, Daejeon, South KoreaChungnam Natl Univ, Coll Vet Med, Dept Vet Internal Med, Daejeon, South Korea
Choi, Seo-In
Rebhun, Robert B.
论文数: 0引用数: 0
h-index: 0
机构:
Univ Calif Davis, Sch Vet Med, Ctr Compan Anim Hlth, Dept Surg & Radiol Sci, Davis, CA USAChungnam Natl Univ, Coll Vet Med, Dept Vet Internal Med, Daejeon, South Korea
Rebhun, Robert B.
Seo, Kyoung-won
论文数: 0引用数: 0
h-index: 0
机构:
Seoul Natl Univ, Coll Vet Med, Dept Vet Internal Med, Seoul, South KoreaChungnam Natl Univ, Coll Vet Med, Dept Vet Internal Med, Daejeon, South Korea