Regulation of proapoptotic proteins Bak1 and p53 by miR-125b in an experimental model of Alzheimer's disease: Protective role of 17β-estradiol

被引：28

作者：

Micheli, F. ^{[1
]}

Palermo, R. ^{[3
]}

Talora, C. ^{[1
]}

Ferretti, E. ^{[2
]}

Vacca, A. ^{[2
]}

Napolitano, M. ^{[1
]}

机构：

[1] Univ Roma La Sapienza, Dept Mol Med, I-00161 Rome, Italy

[2] Univ Roma La Sapienza, Dept Expt Med, Rome, Italy

[3] Ist Italiano Tecnol, Ctr Life Nano Sci Sapienza, Rome, Italy

来源：

NEUROSCIENCE LETTERS | 2016年 / 629卷

关键词：

Alzheimer' disease; mir-125b; 17; beta-Estradiol; PEPTIDE-INDUCED NEUROTOXICITY; CULTURED CORTICAL-NEURONS; CANCER CELLS; EXPRESSION; MICRORNAS; BCL-2; STABILITY; APOPTOSIS; LEUKEMIA;

D O I：

10.1016/j.neulet.2016.05.049

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Alzheimer's disease has become one of the most impacting disorders since world population is rapidly aging. MicroRNA-125b plays a crucial role in many cellular processes and pathologies, but, to date, its role in Alzheimer's disease is controversial. In this study, we demonstrated, for the first time, that the down regulation of miR-125b is a key event for the neurotoxic effect of A beta treatment in cortical neurons. Moreover, we found that 17 beta-estradiol treatment protects neurons from the A beta-peptide induced neurotoxicity by increasing miR-125b expression that, in turn, decreased the expression, both at gene and protein levels, of the pro-apoptopic proteins Bak1 and p53. Overall, our data reveal miR-125b as a novel neuro-protector miRNA in Alzheimer's disease. (C) 2016 Published by Elsevier Ireland Ltd.

引用

页码：234 / 240

页数：7

共 35 条

[21] Oxidative stress activation of miR-125b is part of the molecular switch for Hailey-Hailey disease manifestation [J].

Manca, Sonia ;

Magrelli, Armando ;

Cialfi, Samantha ;

Lefort, Karine ;

Ambra, Roberto ;

Alimandi, Maurizio ;

Biolcati, Gianfranco ;

Uccelletti, Daniela ;

Palleschi, Claudio ;

Screpanti, Isabella ;

Candi, Eleonora ;

Melino, Gerry ;

Salvatore, Marco ;

Taruscio, Domenica ;

Talora, Claudio .

EXPERIMENTAL DERMATOLOGY, 2011, 20 (11) :932-937

[22] 17β-Estradiol protects cerebellar granule cells against β-amyloid-induced toxicity via the apoptotic mitochondrial pathway [J].

Napolitano, Maddalena ;

Costa, Loredana ;

Piacentini, Roberto ;

Grassi, Claudio ;

Lanzone, Antonio ;

Gulino, Alberto .

NEUROSCIENCE LETTERS, 2014, 561 :134-139

[23] Protective effect of pioglitazone, a PPARγ ligand, in a 3 nitropropionic acid model of Huntington's disease [J].

Napolitano, Maddalena ;

Costa, Loredana ;

Palermo, Rocco ;

Giovenco, Alessandro ;

Vacca, Alessandra ;

Gulino, Alberto .

BRAIN RESEARCH BULLETIN, 2011, 85 (3-4) :231-237

[24] Acetylation controls Notch3 stability and function in T-cell leukemia [J].

Palermo, R. ;

Checquolo, S. ;

Giovenco, A. ;

Grazioli, P. ;

Kumar, V. ;

Campese, A. F. ;

Giorgi, A. ;

Napolitano, M. ;

Canettieri, G. ;

Ferrara, G. ;

Schinina, M. E. ;

Maroder, M. ;

Frati, L. ;

Gulino, A. ;

Vacca, A. ;

Screpanti, I. .

ONCOGENE, 2012, 31 (33) :3807-3817

[25] Protective actions of sex steroid hormones in Alzheimer's disease [J].

Pike, Christian J. ;

Carroll, Jenna C. ;

Rosario, Emily R. ;

Barron, Anna M. .

FRONTIERS IN NEUROENDOCRINOLOGY, 2009, 30 (02) :239-258

[26] Neuronal MicroRNA Deregulation in Response to Alzheimer's Disease Amyloid-β [J].

Schonrock, Nicole ;

Ke, Yazi D. ;

Humphreys, David ;

Staufenbiel, Matthias ;

Ittner, Lars M. ;

Preiss, Thomas ;

Goetz, Juergen .

PLOS ONE, 2010, 5 (06)

[27] Expression profiling of mammalian microRNAs uncovers a subset of brain-expressed microRNAs with possible roles in murine and human neuronal differentiation [J].

Sempere, LF ;

Freemantle, S ;

Pitha-Rowe, I ;

Moss, E ;

Dmitrovsky, E ;

Ambros, V .

GENOME BIOLOGY, 2004, 5 (03)

[28] Micro-RNA abundance and stability in human brain: Specific alterations in Alzheimer's disease temporal lobe neocortex [J].

Sethi, Prerna ;

Lukiw, Walter J. .

NEUROSCIENCE LETTERS, 2009, 459 (02) :100-104

[29] Comprehensive survey of human brain microRNA by deep sequencing [J].

Shao, Ning-Yi ;

Hu, Hai Yang ;

Yan, Zheng ;

Xu, Ying ;

Hu, Hao ;

Menzel, Corinna ;

Li, Na ;

Chen, Wei ;

Khaitovich, Philipp .

BMC GENOMICS, 2010, 11

[30] An androgen-regulated miRNA suppresses Bak1 expression and induces androgen-independent growth of prostate cancer cells [J].

Shi, Xu-Bao ;

Xue, Lingru ;

Yang, Joy ;

Ma, Ai-Hong ;

Zhao, Jianjun ;

Xu, Ma ;

Tepper, Clifford G. ;

Evans, Christopher P. ;

Kung, Hsing-Jien ;

White, Ralph W. deVere .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2007, 104 (50) :19983-19988

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