Zein-hyaluronic acid binary complex as a delivery vehicle of quercetagetin: Fabrication, structural characterization, physicochemical stability and in vitro release property

被引：132

作者：

Chen, Shuai ^{[1
]}

Han, Yahong ^{[2
]}

Wang, Yingqi ^{[1
]}

Yang, Xi ^{[1
]}

Sun, Cuixia ^{[1
]}

Mao, Like ^{[1
]}

Gao, Yanxiang ^{[1
]}

机构：

[1] China Agr Univ, Beijing Adv Innovat Ctr Food Nutr & Human Hlth, Beijing Key Lab Funct Food Plant Resources, Coll Food Sci & Nutr Engn,Beijing Lab Food Qual &, Beijing 100083, Peoples R China

[2] China Agr Univ, Coll Engn, Beijing 100083, Peoples R China

来源：

FOOD CHEMISTRY | 2019年 / 276卷

基金：

中国国家自然科学基金;

关键词：

Zein; Hyaluronic acid; Binary complex; Structural characterization; Quercetagetin; NONCOVALENT INTERACTIONS; COLLOIDAL PARTICLES; NANOPARTICLES; ENCAPSULATION; CURCUMIN; POLYSACCHARIDES; LACTOFERRIN; CHITOSAN; ALGINATE; FILMS;

D O I：

10.1016/j.foodchem.2018.10.034

中图分类号：

O69 [应用化学];

学科分类号：

081704 ;

摘要：

The antisolvent coprecipitation method was utilized for fabricating the zein and hyaluronic acid complex at different mass ratios (100:5, 100:10, 100:15, 100:20, 100:25 and 100:30). Results showed that negatively charged zein-hyaluronic acid complex with small size (181.5 nm) was formed through the driving force of electrostatic attraction, followed by hydrogen bonding and hydrophobic effects. The incorporation of hyaluronic acid led to conformational change of zein, and improved its physical and thermal stability. Native hyaluronic acid showed a three-dimensional network structure, while zein-hyaluronic acid binary complex exhibited two different microstructures, including nanoparticles (zein:hyaluronic acid, above 100:20) and particle-filled-microgel (zein:hyaluronic acid, below 100:20). In addition, zein-hyaluronic acid complex was designed as a new delivery vehicle to anti-thermal degradation and control release of quercetagetin. These findings indicated that zein-hyaluronic acid complex would be a useful and promising delivery vehicle for embedding and protecting bioactive compounds.

引用

页码：322 / 332

页数：11

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