C-2 Arylation of Piperidines through Directed Transition-Metal-Catalyzed sp3 C-H Activation

被引：101

作者：

Prokopcova, Hana ^{[1
]}

Bergman, Sheba D. ^{[1
]}

Aelvoet, Karel ^{[1
]}

Smout, Veerle ^{[1
]}

Herrebout, Wouter ^{[1
]}

Van der Veken, Benjamin ^{[1
]}

Meerpoel, Lieven ^{[2
]}

Maes, Bert U. W. ^{[1
]}

机构：

[1] Univ Antwerp, B-2020 Antwerp, Belgium

[2] Johnson & Johnson Pharmaceut Res & Dev, Div Janssen Pharmaceut NV, B-2340 Beerse, Belgium

来源：

CHEMISTRY-A EUROPEAN JOURNAL | 2010年 / 16卷 / 44期

关键词：

C-H activation; hydrogen; homogeneous catalysis; piperidines; ruthenium; HYDROGEN BOND-CLEAVAGE; ORGANIC-SYNTHESIS; COUPLING REACTION; NITROGEN ATOM; FUNCTIONALIZATION; CARBONYLATION; HETEROCYCLES; COMPLEXES; ADJACENT; ALKYLAMINES;

D O I：

10.1002/chem.201001887

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

All you need is an open vial! The direct α arylation of cyclic alkylamines (see scheme) requires an open vial, as the hydrogen atom involved in the C(sp3)-H-activation process is ultimately released as hydrogen gas. Reports on the formation of hydrogen gas in direct transition-metal- catalyzed functionalizations are still rare. Open-vial reactions proved crucial to this direct arylation procedure as, upon sealing, catalyst deactivation occurs. © 2010 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

引用

页码：13063 / 13067

页数：5

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