Aging reduces the functionality of anti-pneumococcal antibodies and the killing of Streptococcus pneumoniae by neutrophil phagocytosis

被引：123

作者：

Simell, Birgit ^{[1
]}

Vuorela, Arja ^{[1
]}

Ekstrom, Nina ^{[1
]}

Palmu, Arto ^{[1
]}

Reunanen, Antti ^{[2
]}

Meri, Seppo ^{[3
]}

Kayhty, Helena ^{[1
]}

Vakevainen, Merja ^{[1
]}

机构：

[1] Natl Inst Hlth & Welf, Dept Vaccinat & Immune Protect, Helsinki 00300, Finland

[2] Natl Inst Hlth & Welf, Dept Living Condit Hlth & Wellbeing, Helsinki 00300, Finland

[3] Univ Helsinki, Dept Bacteriol & Immunol, Haartman Inst, Helsinki, Finland

来源：

VACCINE | 2011年 / 29卷 / 10期

基金：

芬兰科学院;

关键词：

Pneumococcal; Aging; Immune function; AGE-RELATED DECLINE; POLYSACCHARIDE VACCINE; CONJUGATE VACCINE; IMMUNE-RESPONSES; CAPSULAR POLYSACCHARIDES; COMPLEMENT ACTIVITY; IMMUNOGLOBULIN-G; INNATE IMMUNITY; ELDERLY ADULTS; OTITIS-MEDIA;

D O I：

10.1016/j.vaccine.2010.12.121

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

We evaluated the effect of aging on the functional activity of naturally acquired anti-pneumococcal antibodies, the function of neutrophils in phagocytic killing of opsonized pneumococci, and the complement activity. Opsonic activities of antibodies to all tested pneumococcal serotypes were significantly lower and phagocytic killing of pneumococci by neutrophils was significantly impaired among the elderly, whereas the complement activity was slightly higher in the elderly than in the young adults. The reduced functional activity of serotype-specific antibodies and the compromised function of neutrophils in the opsonophagocytosis of pneumococci are likely to contribute to the increased susceptibility of the elderly to pneumococcal diseases. (C) 2011 Elsevier Ltd. All rights reserved.

引用

页码：1929 / 1934

页数：6

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