Pathophysiology of neonatal hyperbilirubinemia

被引：0
|
作者：
Vert, P [1 ]
机构：
[1] Matern Reg A Pinard, Serv Med & Reanimat Neonatales Genet, F-5402 Nancy, France
来源：
ARCHIVES DE PEDIATRIE | 1998年 / 5卷 / 09期
关键词：
bilirubin; infant; newborn; jaundice; transferases; toxicology;
D O I：
暂无
中图分类号：
R72 [儿科学];
学科分类号：
100202 ;
摘要：
The most important steps of bilirubin metabolism involved in the pathophysiology of neonatal hyperbilirubinemia are: 1) hemoglobin degradation by heme oxygenase; 2) bilirubin binding to serum albumin; 3) bilirubin conjugation to acid glucoronic by glucoronyl transferase. Progresse in the knowledge of these metabolic steps allows to understanding of why massive hemolysis, infections, hypoxia and prematurity increase the risk of kernicterus and therefore justify adapted preventive and therapeutic measures. (C) 1998 Elsevier, Paris.
引用
收藏
页码：1028 / 1030
页数：3
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